An enzyme induced by stress to help reduce production of damaging free radicals is also used by liver cancer to regulate two major cell proliferation pathways that enable the cancer to thrive, scientists report.
Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers. Using the Swiss Light Source, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.
Researchers have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma -- the most common and also the most lethal form of pancreatic cancer.
A new computational tool called ProtFus screens scientific literature to validate predictions about the activity of fusion proteins -- proteins encoded by the joining of two genes that previously encoded two separate proteins. Somnath Tagore in the Frenkel-Morgenstern Lab at Bar-Ilan University, Israel, and colleagues present ProtFus in PLOS Computational Biology.
New research is showing the profound benefits -- for longevity and fighting disease -- of intermittent fasting.
A team led by Texas A&M University's College of Veterinary Medicine & Biomedical Sciences' (CVM) researcher Dr. Stephen Safe has discovered a new pathway that may help suppress the development of glioblastoma tumors, one of the deadliest forms of cancer.
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
A team of researchers in the Marcia group at EMBL Grenoble, France, have discovered that the tumour suppressor MEG3 adopts a complex three-dimensional structure to fulfil its function. Furthermore, they were able to fine-tune its activity by targeted manipulation of this architecture. The results of this study, published in Molecular Cell, might help to advance diagnosis and treatment of certain types of cancer.
CNIO researchers have identified the role played by mTOR pathway as the origin of follicular lymphoma and propose the exploration in future studies of a possible therapeutic strategy using a drug that is already being used in clinical practice to treat other tumors.
In an extensive 'data mining' analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost -- albeit slightly -- the risk of developing colon cancer -- but not rectal cancer -- a decade later.