A team led by Texas A&M University's College of Veterinary Medicine & Biomedical Sciences' (CVM) researcher Dr. Stephen Safe has discovered a new pathway that may help suppress the development of glioblastoma tumors, one of the deadliest forms of cancer.
One way biological compounds inside cells stay organized is through membrane-less organelles (MLOs) -- wall-less liquid droplets made from proteins and RNA that clump together and stay separate from the rest of the cellular stew. In a paper in Scientific Reports, scientists report that MLOs may be highly sensitive to the level of divalent cations inside cells. This matters because divalent calcium and magnesium ions aid in cellular signaling and are vital to life.
CNIO researchers have identified the role played by mTOR pathway as the origin of follicular lymphoma and propose the exploration in future studies of a possible therapeutic strategy using a drug that is already being used in clinical practice to treat other tumors.
Simple, fast and flexible: it could become significantly easier to vaccinate plants against viruses in future. Scientists at Martin Luther University Halle-Wittenberg (MLU), the Leibniz Institute of Plant Biochemistry (IPB) and the National Research Council in Italy (CNR) have developed a new method for this purpose. It enables the rapid identification and production of precisely tailored substances that combat different pathogens. The researchers discuss their work in the next edition of Nucleic Acids Research.
Pollution of lakes is a worldwide problem. Restoration attempts take a lot of time and effort, and even then they might backfire. A team of researchers led by the Netherlands Institute of Ecology (NIOO-KNAW) suggests a different approach. First, you have to determine to which of four different types your lake belongs, they write in the August issue of Science of the Total Environment. Spatial differences are the key to a successful restoration recipe.
A globally important ocean algae is mysteriously scarce in one of the most productive regions of the Atlantic Ocean, according to a new paper. A massive dataset has revealed patterns in the regions where Atlantic coccolithophores live, illuminating the inner workings of the ocean carbon cycle and raising new questions.
The lab of Cheryl Kerfeld at Michigan State University has created a synthetic nano-sized factory, based on natural ones found in bacteria. This research could someday lead to new medical, industrial or bioenergy applications.
Brain abnormalities in people at familial risk of schizophrenia and bipolar disorder emerge in unique patterns, despite the symptom and genetic overlap of the disorders, according to a study in Biological Psychiatry, published by Elsevier. Similarities between schizophrenia and bipolar disorder have led to the diagnoses being increasingly combined in studies of psychosis, but the findings highlight that risk for the disorders has distinct effects on the brain.
An integrated approach that unifies psychosocial factors with neurobiology sheds light on chronic pain traits and their underlying brain networks, according to a study published Aug. 20, 2019 in the open-access journal PLOS Biology by A. Vania Apkarian of Northwestern University Feinberg School of Medicine, and colleagues.
The effectiveness of current anti-clotting medication can be limited due to the risk of complications. This is driving a need for alternatives that can both prevent the formation of blood clots and reduce the risk of excessive and life-threatening bleeding. A new biocompatible lab-on-a-chip could help accelerate the discovery and development of new anti-clotting therapies, with automated processes that can achieve in a few minutes what could take days in a full-sized lab.