All life is cellular, but the origins of cellularity remain unknown. Scientists at the Earth-Life Science Institute have discovered that simple organic compounds like glycolic and lactic acid polymerize and self-assemble into cell-sized droplets when dried and rewetted, as might have happened along primitive beaches and drying puddles. These cell-like compartments can trap and concentrate biomolecules, and can merge and separate, forming versatile and heterogeneous cell-like containers possibly critical for the origin of life.
The August edition of SLAS Technology features the cover article, 'Technologies for the Directed Evolution of Cell Therapies,' a review featured in the journal's March 2019 edition. The research, led by Dino Di Carlo, Ph.D., (University of California Los Angeles) highlights how the next generation of therapies are moving beyond the use of small molecules and proteins to using whole cells.
In new research published in Proceedings of the National Academy of Sciences, Hollis Cline, Ph.D., and her colleagues at Scripps Research shed new light on the role that exosomes play in brain development. They show that exosomes are not only integral to the development of neurons and neural circuits, but they can restore health to brain cells affected by developmental disease.
Virginia Tech researcher Clément Vinauger has discovered new neurobiology associated with mosquito vision and sense of smell that explains how Aedes aegypti mosquitoes track their victims.
Almost all living organisms have gate-like protein complexes in their cell membranes that get rid of unwanted or life-threatening molecules. These ABC transporters are also responsible for resistance to antibiotics or chemotherapy. Researchers at Goethe University Frankfurt, together with the Max Planck Institute of Biophysics, which is also located in Frankfurt, have now succeeded in decrypting all the stages of the transport mechanism.
People who follow the paleo diet have twice the amount of a key blood biomarker linked closely to heart disease, the world's first major study examining the impact of the diet on gut bacteria has found.
An international team including University of Warwick scientists identifies proteins that drive activation of our immune response. Adaptor proteins act as a 'clutch' to move clusters of proteins within cells Could open opportunities to design immune cells to combat specific problems. Protein condensates are involved; have been found to play roles in many biological processes and diseases, including Huntington's disease, amyotrophic lateral sclerosis, and types of cancer.
Epileptic seizures happen in one of every 10 people who have experienced a traumatic brain injury (TBI). However, new research at The University of Texas at San Antonio (UTSA) has uncovered an innovative approach to possibly slow the progression of epilepsy. Researchers at UTSA have successfully removed new neurons that have developed after a brain injury to reduce seizures in mice. They believe that the technique could potentially reduce post-injury epilepsy.
Destructive free radicals -- known as reactive oxygen species -- are thought to degrade the cells of phytoplankton and other organisms. A new paper, however, suggests that these molecules actually play a beneficial role, upending some conventional wisdom.
A new mathematical model describes how highly concentrated antibody solutions separate into different phases, similar to an oil and water mixture, which can reduce the stability and shelf-life of some drugs.