A laboratory at the CDI has discovered a highly sensitive methodology that can efficiently find and harness EVs -- particularly exosomes and the micro RNAs they carry. These could be crucial clues to early identification of diseases like cancer
Researchers at the MDC, the BIH and Charité have developed methods for performing comprehensive analyses of fixed tumor tissue samples. These analyses make it possible to shed new light on the clinical course of various cancer types, as the team reports in "Nature Communications".
Researchers from Tokyo Medical and Dental University (TMDU) have found that the urinary secretion of uromodulin, a kidney-specific protein, can be increased by the hormone vasopressin via certain signaling pathways. Increasing the urinary secretion of uromodulin may protect against urinary tract infections and kidney stones, while the resulting lower uromodulin levels in kidney cells may help to prevent hypertension and chronic kidney disease.
Russian scientists have developed a simple and easily reproducible cell labeling system that allows tracking the behavior and movement of individual cells when solving problems that require maximum accuracy.
Researchers at the Cluster of Excellence CIBSS - Centre for Integrative Biological Signalling Studies develop technology to introduce genes into single cells in a targeted manner.
Preclinical research finds that glioblastoma stem cells can be targeted by NK cells, but they are able to evade immune attack by releasing TFG-β. Deleting the TFG-β receptor in NK cells renders them resistant to this and restores their anti-tumor activity.
Research conducted by Qiang et al has discovered a link between a protein in red blood cells and age-related decline in cognitive performance. Published in the open access journal PLOS Biology on June 17, 2021, the study shows that depleting mouse blood of the protein ADORA2B leads to faster declines in memory, delays in auditory processing, and increased inflammation in the brain.
Researchers from Nara Institute of Science and Technology have found that an anchoring complex in plant cells recruits its own version of the katana sword for cutting microtubules. The Msd1-Wdr8 complex is used to stabilize sites within plant cells where new microtubules are created, before it recruits katanin -- an enzyme named after the katana sword -- to cut and release new microtubules. This research will inform future studies on cell biology in plants and animals.
A new treatment approach focused on fixing cell damage, rather than fighting the virus directly, is effective against SARS-CoV-2 in lab models. Combination of two drugs reduces spread of SARS-CoV-2 infection in cells by up to 99.5%. If found safe for human use, this anti-viral treatment would make COVID-19 symptoms milder and speed up recovery times.
Scientists have identified key molecular events in the developing human embryo between days 7 and 14 -- one of the most mysterious, yet critical, stages of our development.