Microplastic pollution of waterways has become a huge concern, with the tiny pieces of plastic entering food webs and potentially having harmful effects on animals and people. In addition, microplastics can act as breeding grounds for antibiotic-resistant bacteria. Now, researchers reporting in Environmental Science & Technology have analyzed antibiotic-resistance genes (ARGs) on five types of microplastics at different locations along the Beilun River in China, finding much higher abundances in urban than rural regions.
CNIO researchers have found out how PrimPol protein helps the cell to survive the damage caused by chemotherapy and plan to use this knowledge to enhance cancer treatments.
Through a pre-clinical study conducted in his former role at Moffitt Cancer Center and published in Clinical Cancer Research, Said Sebti, Ph.D., associate director for basic research at VCU Massey Cancer Center, identified a novel drug that effectively thwarts pancreatic tumors that are addicted to the cancer-causing mutant KRAS gene.
Researchers at Baylor College of Medicine have identified a protein signaling mechanism driving join dysfunction in OI and find that inhibiting this signaling pathway can prevent onset of tendinopathy problems in mouse models.
Researchers at the Human Genome Sequencing Center at Baylor College of Medicine have identified genetic variant discrepancies between the hg19 and hg28 reference genomes, creating guidance for laboratories to take advantage of an improved human reference genome.
A new USC study not only sheds light on how the APOE4 gene may cause some of the pathologies associated with Alzheimer's disease, but also suggests a new treatment target that might help people who carry the APOE4 gene in early and late stages of the disease. USC researchers found that APOE4 is associated with the activation of an inflammatory protein that causes a breakdown in the blood-brain barrier which protects the brain.
In polymicrogyria, the cortex of the brain has irregular, small folds and disorganization in its cell layers, leading to intellectual/developmental disability and epilepsy. This study of four patients with polymicrogyria caused by a mutation in the gene ATP1A3 revealed surprises about the role of a common ion channel pump in early brain development.
A large-scale ethnically diverse genetic study involving USC researchers has expanded what is known about potential causes of type 2 diabetes. The genome-wide meta-analysis has identified more regions of the genome that are linked to blood glucose and insulin levels, features that contribute to the risk of type 2 diabetes. The findings demonstrate that a significant minority of genes linked to glucose and insulin levels are present in only one or two ethnic groups.
A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia. The findings, published in Alzheimer's Research & Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer's, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment.
The scientific world has been delving ever deeper into cancer, scourging for even the tiniest biomolecule that could amp up the cure for the deadly disease. A recent discovery in this regard is the gene LIM domain only 1, whose coded protein has a role in tumor formation. In a new article in Chinese Medical Journal, researchers have reviewed studies detailing molecular features of this gene for potential practical applications in cancer cure.