So far, only a handful of siRNA, or other RNA interference-based therapeutics that can shut down harmful genes to keep viruses from spreading have been approved. Chemical engineering researchers in the Cockrell School of Engineering have created several nanoparticles to help solve the problem of getting the siRNA into the body and guiding it to the target.
Following the progression of breast cancer in an animal model revealed a path that transforms a slow-growing cancer type known as estrogen receptor (ER)+/HER2+ into a fast-growing ER-/HER2+ type that aggressively spreads or metastasizes to other organs.
Mitochondria - the 'batteries' that power our cells - play an unexpected role in common diseases such as type 2 diabetes and multiple sclerosis, concludes a study of over 350,000 people conducted by the University of Cambridge. The study, published today in Nature Genetics, found that genetic variants in the DNA of mitochondria could increase the risk of developing these conditions, as well influencing characteristics such as height and lifespan.
Researchers from the Spanish National Cancer Research Centre (CNIO) and the IDIBELL, led by Eva González-Suárez at the CNIO, have found that the hyperactivation of the RANK pathway plays a double function in breast cells: in the early stages of cancer, it activates senescence, which has a protective effect and delays the appearance of tumours; in more advanced stages, RANK-induced senescence favours the accumulation of stem cells, which promotes tumour growth and aggressiveness.
New research has shown that people with type 1 diabetes may have features of premature heart disease induced by the condition often before they even get their diagnosis.
The study suggests that the SWI/SNF complex may be a tumour suppressor and DNA-RNA hybrids could be an important source of tumour generation
Researchers from Tokyo Medical and Dental University (TMDU) have demonstrated that delivering oxygen via the rectum as a gas or in an oxygen-rich liquid can support oxygen provision to organs and tissues during respiratory failure. Such "enteral ventilation" increased oxygenation, improved behavior and prolonged survival in experimental mouse and pig models of respiratory failure. Further research may allow its clinical application in human patients as a less invasive alternative to ventilators and artificial lungs.
Scientists from China have sequenced and analyzed the genome of lavender to provide insights into what causes its distinct aroma. Their findings shed light into the evolution of this uniquely fragrant plant, which could pave the way for creating improved lavender varieties besides adding to existing knowledge on the evolution, phytochemistry, and ecology of Lamiaceae, the plant family to which lavender belongs.
A new study's findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist's office.
A new whole genome sequence for the Yap hadal snailfish provides insights into how the unusual fish survives in some of the deepest parts of the ocean. Xinhua Chen of the Fujian Agriculture and Forestry University and Qiong Shi of the BGI Academy of Marine Sciences published their analysis of the new genome May 13th in the journal PLOS Genetics.