Researchers at the Cluster of Excellence CIBSS - Centre for Integrative Biological Signalling Studies develop technology to introduce genes into single cells in a targeted manner.
Researchers from the Hospital del Mar and Pompeu Fabra University have confirmed that messenger RNA vaccines pre-prepared in syringes for their administration can be transported by road for up to three hours. The researchers have conducted stress tests on syringes pre-prepared for administering the Pfizer BioNTech and Moderna vaccines, and have found that the vector these vaccines use, the messenger RNA, maintains its integrity despite being subjected to movement.
Researchers from Hiroshima University now have a better understanding of the mechanism underlying how certain bacteria can transfer genetic material across taxonomic kingdoms, including to fungi and protists. Their work, published in Frontiers in Microbiology, could have applications in changing how bacteria perform certain functions or react to changes in their environment.
Forsight to present clinical data of their blood-based MRD detection platform for DLBCL that detects relapse 200 days earlier than other methods.
Preclinical research finds that glioblastoma stem cells can be targeted by NK cells, but they are able to evade immune attack by releasing TFG-β. Deleting the TFG-β receptor in NK cells renders them resistant to this and restores their anti-tumor activity.
Research conducted by Qiang et al has discovered a link between a protein in red blood cells and age-related decline in cognitive performance. Published in the open access journal PLOS Biology on June 17, 2021, the study shows that depleting mouse blood of the protein ADORA2B leads to faster declines in memory, delays in auditory processing, and increased inflammation in the brain.
Researchers from Nara Institute of Science and Technology have found that an anchoring complex in plant cells recruits its own version of the katana sword for cutting microtubules. The Msd1-Wdr8 complex is used to stabilize sites within plant cells where new microtubules are created, before it recruits katanin -- an enzyme named after the katana sword -- to cut and release new microtubules. This research will inform future studies on cell biology in plants and animals.
Scientists have identified key molecular events in the developing human embryo between days 7 and 14 -- one of the most mysterious, yet critical, stages of our development.
The yellow fever mosquito (scientific name, Aedes aegypti) spreads multiple untreatable viruses in humans and is primarily controlled using a pesticide called permethrin. However, many mosquitoes are evolving resistance to the pesticide. A new study by Karla Saavedra-Rodriguez of Colorado State University and colleagues, published in the journal PLOS Genetics, identifies mutations linked to different permethrin resistance strategies, which threaten our ability to control disease outbreaks.
Researchers from Osaka University, along with international collaborators in Europe, have identified Thrombospondin-2 as a serum biomarker that confirms and stratifies the progressive complications of nonalcoholic fatty liver disease. This research may form the basis of a new noninvasive approach that can provide an early warning system for nonalcoholic steatohepatitis and advanced fibrosis and may predict progression to cirrhosis, liver failure and even cancer.