September's SLAS Discovery cover article, "Using physicochemical measurements to influence better compound design,' now available for 30 days.
The cryoEM structure of a simian immunodeficiency virus protein bound to primate proteins shows how a mutation in early humans allowed our ancestors to escape infection while monkeys and apes did not. SIV's Nef protein forms a solid link between two primate proteins, tetherin and AP-2, forcing the destruction of tetherin, which normally prevents new SIV virions from budding off. A mutation in human tetherin disrupted binding, thwarting SIV budding -- until HIV evolved a work-around.
IST Austria scientists determine the first structure of a cell's rotary engine using state-of-art microscopy.
Over the last 40 years, the Asian tiger mosquito, Aedes albopictus, has invaded every continent thanks to the transportation of its eggs via human trade and transportation. Researchers reporting in PLOS Neglected Tropical Diseases have now used the genomes of the mosquitos to track the history of the invasion and expansion of the species through Albania, Italy, and Greece.
A team of scientists from Weill Cornell Medicine and The Rockefeller University has illuminated the basic mechanism of Piezo proteins, which function as sensors in the body for mechanical stimuli such as touch, bladder fullness, and blood pressure. The discovery is a feat of basic science that also opens up many new paths of investigation into the roles of Piezo proteins in human diseases and potential new therapeutic strategies.
A team of researchers in the Marcia group at EMBL Grenoble, France, have discovered that the tumour suppressor MEG3 adopts a complex three-dimensional structure to fulfil its function. Furthermore, they were able to fine-tune its activity by targeted manipulation of this architecture. The results of this study, published in Molecular Cell, might help to advance diagnosis and treatment of certain types of cancer.
CNIO researchers have identified the role played by mTOR pathway as the origin of follicular lymphoma and propose the exploration in future studies of a possible therapeutic strategy using a drug that is already being used in clinical practice to treat other tumors.
Scientists from the University of California, Irvine School of Biological Sciences have discovered how to forestall Alzheimer's disease in a laboratory setting, a finding that could one day help in devising targeted drugs that prevent it. The researchers found that by removing brain immune cells known as microglia from rodent models of Alzheimer's disease, beta-amyloid plaques -- the hallmark pathology of AD -- never formed. Their study will appear Aug. 21, 2019 in the journal Nature Communications.
A new study from the Allen Institute for Brain Science has written the most detailed 'parts list' of the human brain to date. This categorization of our brain cell types lays the groundwork to improve our understanding of our own brains and to dramatically change how we treat human brain diseases and disorders.
Biomedical engineers at Duke University have discovered that an adenosine receptor called A2B can be pharmaceutically activated to reverse bone degradation caused by osteoporosis in mouse models of the disease.