Mathematical modeling suggests that the rate at which a patient's immune system clears slow-growing variants of methicillin-resistant Staphylococcus aureus (MRSA) bacteria is a key determinant of whether antibiotics can cure the infection. Tsuyoshi Mikkaichi and Alexander Hoffmann of the University of California, Los Angeles, and the MRSA Systems Immunobiology Group present this work in PLOS Computational Biology.
A new computational model successfully predicts how daily pain sensitivity rhythms affect pain processing, both in healthy adults and in people with neuropathic pain. Jennifer Crodelle of New York University and colleagues present these findings in PLOS Computational Biology.
Death metal band logos often have a spiky look while romance novel titles often have a swirly script. The jaggedness or curviness of a font can be used to express an emotional tone. A Dartmouth study published in the Proceedings of the Royal Society B finds that sounds, shapes, speech and body movements convey emotional arousal the same way across the senses. The findings explain why nearly anything can have an emotional tone, including art, architecture and music.
Researchers studying the impact of fatigue on athletic performance have developed prototype software that can enable coaches to predict when elite athletes will be too fatigued to perform at their best.
Mathematics is seen as the pinnacle of abstract thinking. But are we capable of filtering out our knowledge about the world to prevent it from interfering with our calculations? Researchers (UNIGE) have demonstrated that our ability to solve mathematical problems is influenced by non-mathematical knowledge, which results in mistakes. The findings indicate that high-level mathematicians can be duped by some aspects of their knowledge about the world and fail to solve primary school-level subtraction problems.
Accountable care organizations (ACOs), the health care delivery model created by the Affordable Care Act in an effort to reduce Medicare costs while improving coordination and quality of care, typically rely on primary care providers (PCPs) to steer the boat.
A bioengineering group from the University of Pittsburgh is bringing the worlds of computational modeling and experimentation closer together by developing a methodology to help analyze the wealth of imaging data provided by advancements in imaging tools and automated microscopes. They recently published a paper in PLOS ONE that shows how using approximate Bayesian computation (ABC) can help infer useful quantitative information for experimental design.
Mathematicians' new modeling has identified major sources of interspecies and inter-individual variations in the clinical efficacy of a clock-modulating drug: photosensitivity and PER2 level. This enabled precision medicine for circadian disruption.
IBS research team reveals a considerable chance for an ice-free Arctic Ocean at global warming limits stipulated in the Paris Agreement.
A Penn study of more than 150,000 men with prostate cancer shows androgen deprivation therapy was associated with a higher likelihood of developing dementia when compared to patients who were not exposed to the treatment.