How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities.
Similar to the dozens of Sherpas that guide hikers up treacherous Himalayan mountains to reach a summit, the nervous system relies on elaborate timing and location of guidance cues for neuronal axons--threadlike projections--to successfully reach their destinations in the body. Now, Salk Institute researchers discover how neurons navigate a tricky cellular environment by listening for directions, while simultaneously filtering out inappropriate instructions to avoid getting lost.
Current treatments for tuberculosis (TB) are very effective in controlling TB infection caused by Mycobacterium tuberculosis (Mtb). They don't, however, always prevent reinfection. Why this happens is one of the long-standing questions in TB research. A team of scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University may have found the answer... in the gut.
Ryerson University Physicist Dr. Michael Kolios, his former graduate student Dr. Michael Moore, and collaborator zebrafish model expert Dr. Xiao-Yan Wen developed a new mode of photoacoustic imaging called F-mode. This new mode selectively enhances photoacoustic image features based on the size of the object and the sounds it produces.
While the importance of trusted relationships between patients and their physicians is taken for granted, little attention has been given to the relationships among physicians themselves. Yet the interactions between, for example, a patient's primary care physician and cardiologist or between a patient's pediatrician and an oncology team, are essential to the safety and quality of care for patients and the resilience of physicians and other healthcare professionals.
Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers.
There are currently more than three million people in the US with hepatitis C, a condition that can lead to serious and even deadly liver complications. In the US prison system, the prevalence of hepatitis C virus (HCV) infection is currently 10 times higher than the national average. However, new research in the INFORMS journal Operations Research, has identified new protocols that could substantially decrease HCV infection in the US prison system.
In a surprising finding, researchers at the University of Michigan Rogel Cancer Center showed the protein NLRP6 aggravated the difficult symptoms of gastrointestinal graft-vs.-host disease. Knocking out this protein in mice led to significantly better survival and less severe GVHD.
Striking colors that are seen only in the males of some species are partly explained by gene behavior, research into guppy fish suggests.
A sophisticated new analysis too incorporating advanced mathematical strategies could help revolutionize the way researchers investigate the spread and distribution of dangerous, fast-evolving disease vectors.