Researchers at Beth Israel Deaconess Medical Center embarked on a study to investigate whether early changes in energy-related metabolites in the blood -- measured shortly after chemotherapy -- could be used to identify patients who developed heart toxicity at a later time.
A combination of chemotherapy drugs during brain cancer surgery using a biodegradable paste, leads to long-term survival, researchers at the University of Nottingham have discovered.
Many women find themselves skipping scientific conferences because of family obligations, a new study finds. Women were less likely than men to attend scientific meetings, although both genders noted that conferences were important to career advancement.
Researchers at the University of Sussex have identified how differences in the genetic sequence of the two main strains of the cancer-associated Epstein-Barr virus (EBV) can alter the way the virus behaves when it infects white blood cells.
Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system. The investigators also reported on the pre-clinical development of a new therapy, which, when given in combination with existing immunotherapies, appears to stop and even reverse metastasis in mouse models.
Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells. Researchers studied the effects of low doses of radiation in mice and found it increases the number of cells with mutations in p53, a well-known genetic change associated with cancer. However, giving the mice an antioxidant before radiation promoted the growth of healthy cells, which outcompeted and replaced the p53 mutant cells.
A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth.
Under physiological conditions, only certain sequences within the genome, called flipons, are capable of dynamically forming either right- or left-handed DNA. When a flipon is left-handed, genes change the transcripts they produce, affecting how cells respond to their environment. The outcomes depend on both the shape and sequence of a gene's DNA, each feature encoding a different subset of genetic information: one dynamic, the other static. Both flipons and codons are subject to natural selection.
A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published today in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, it can prevent the cancer from being recognized and destroyed by the immune system.
A University of Massachusetts Amherst environmental epidemiologist studying the presence of PFAS compounds in new mothers and their babies found that women with gestational diabetes had a 'significantly higher' rate of transferring the synthetic chemicals to their fetus.