A dangerous protein named SNAI2 helps cancers metastasize and shields cancer from both the immune system and chemotherapy. Worse, SNAI2 is in a family of proteins that are notoriously hard to fight with drugs. But now Princeton University's Yibin Kang and his colleagues have found a way to use the cell's recycling system to control SNAI2, providing a new possibility for treatments.
Breast cancer patients whose disease has spread to their brains fare better if their metastases are picked up before they begin to cause symptoms, according to a study presented at the 12th European Breast Cancer Conference.
Researchers studying the activity of gut bacteria in breast cancer patients have found a possible link with how well their chemotherapy works.
Researchers investigated differences in quality of life and other outcomes (including physical functioning, body image, sexual health, anxiety and depressive symptoms) by type of breast cancer surgery (such as mastectomy or breast conserving surgery) in women 40 and younger.
A blood test that can identify a variety of mutations in advanced breast cancer can reliably match women to effective targeted treatments, early results of a major clinical trial reveal.
Biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue, reports a new study. These sex differences are observed for genes involved in many functions, including how people respond to medication, how women control blood sugar levels in pregnancy, how the immune system functions, how cancer develops and male pattern baldness. The information could be used for diagnostics, drug development and predicting outcomes.
Researchers isolated eight novel polyphenols from the rarest type of propolis. Two of them were found to inhibit tumor cell proliferation in laboratory assays.
Researchers at the George Washington University have found that the hair loss drug spironolactone is not associated with increased risk of female breast cancer recurrence and may be safe to treat female pattern hair loss in breast cancer survivors. Their findings are published in the Journal of the American Academy of Dermatology.
The study, published in the scientific journal Nature, has uncovered a genetic vulnerability present in nearly 10% percent of all breast cancers tumours, and found a way to target this vulnerability and selectively kill cancer cells.
First-in-class drug starves certain tumor types of the resources they need to grow and spread to other parts of the body.