First head-to-head comparison of CDK4/6 inhibitors in cell line and animal models of breast cancer reveals important differences, including one drug that exhibits unique, potentially advantageous therapeutic activity.
Moffitt Cancer Center researchers hope to change this mindset for radiation treatment with the development of a genomically-based model that can optimize and personalize a radiation dose to match an individual patient's needs.
Like many women who develop a particular type of breast cancer, the same gene -- HER2 -- also appears to be the cause of lung cancer in many dogs. TGen and Ohio State found that neratinib -- a drug that has successfully been used to battle human breast cancer -- might also work for many of the nearly 40,000 dogs in the US that annually develop the most common type of canine lung cancer, known as CPAC.
Survivors from a wide range of cancers could experience increased risks of heart disease and blood circulation problems compared to those who have never had cancer, according to new estimates published in the Lancet.
The U.S. Preventive Services Task Force offers new guidelines on BRCA1/2 genetic testing. Susan Domchek, MD, writes in JAMA that there is more the medical community should be doing to connect at-risk patients with the most thorough and helpful genetic information.
A new study led by investigators from Brigham and Women's Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. The results of the study are published today in Science Signaling.
The US Preventive Services Task Force (USPSTF) is broadening its recommendation on screening for potentially harmful mutations of the breast cancer susceptibility BRCA1/2 genes, which are associated with increased risk of certain cancers. The USPSTF now recommends primary care clinicians assess risk in women with a personal or family history of breast, ovarian, fallopian tube, or peritoneal (tissue lining the abdominal cavity) cancer or those who have an ancestry associated with BRCA1/2 mutations.
Women with severe sleep apnea appear to be at an elevated risk of getting cancer, a study shows. No causal relationship is demonstrated, but the link between nocturnal hypoxia in women and higher cancer risk is still clear.
With the help of new technology, the researchers of the University of Turku in Finland have gained more detailed information on the diversity of the human lymphatic system than before. The research results can help to understand the human defence mechanisms on the molecular level even better than before. Several cancers, such as breast cancer and head and neck cancers, spread primarily via the lymphatic system.
Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study from the University of North Carolina at Chapel Hill Gillings School of Global Public Health, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.