Researchers from NUS Yong Loo Lin School of Medicine's Infectious Diseases Translational Research Programme have discovered that the use of a common antibiotic, doxycycline, in combination with TB drug treatment, reduces the size of lung cavities and accelerates markers of lung recovery. This was done in a trial with 30 pulmonary tberculosis patients.
University of Minnesota Medical School researchers determined that the common blood pressure medication, losartan, is not effective in reducing hospitalization for mildly-ill COVID-19 outpatients.
German RABBIT registry data -- Elderly people with rheumatoid arthritis (RA) are generally at increased risk of serious infections. At the same time, some anti-rheumatic treatments have been associated with a higher serious infection risk, but the extent to which older people are exposed to higher risks with some newer classes of therapy is an open question. Results of this study suggest that treatment with new classes of drugs is not associated with an increased risk of serious infection in elderly patients above 70 years of age.
A new scientific study published in Nature Catalysis shows that baker's yeast can be designed and optimised to produce polyamines and polyamine analogues for tackling grand challenges in both the health and agricultural sector.
A decade-long study of distal radius fracture revealed that personalized medicine catering to a patient's individual needs and environment, not age or X-rays, should guide treatment options. This federally funded study is the most intense, collaborative effort to answer a 200-year puzzle about how to treat the most common forearm fracture in older adults.
KIYATEC announces clinical study data showing test accurately predicts brain cancer patient response to standard drug therapy prior to treatment.
In the international prospective multicenter crossover LEADER-75 trial, comparison of reduced-dose gadobutrol and standard-dose gadoterate versus unenhanced imaging demonstrated noninferiority using 20% margin for three primary efficacy measures; mean readings differed by less than 1%, supporting equivalence using a narrow ±5% margin. Various secondary variables also supported non-inferiority of reduced-dose gadobutrol.
While stents are highly effective, scarring or clotting of unhealed stents can occur and lead to complications. Approaches to understand stent healing based on their biological clotting status is unavailable in patients. To devise a potential solution, Dr. Jason McCarthy, an Associate Professor at MMRI, and his team developed a fluorescent probe that binds to activated platelets, allowing the potential for clinicians to proactively treat patients before the development of occlusive stent clotting or scarring.
In recent years, significant progress has been made towards the use of high-resolution peripheral computed tomography (HR-pQCT) imaging in research, and new potential for applications in the clinic have emerged. This new publication by the Joint IOF-ASBMR-ECTS HR-pQCT Working Group provides an important overview of current clinical applications of HR-pQCT in adults, valuable guidance on interpretation of results, and a summary of novel applications and future directions.
Forsight to present clinical data of their blood-based MRD detection platform for DLBCL that detects relapse 200 days earlier than other methods.