A Cochrane Review into the effectiveness of hospital-based specialist palliative care has found evidence that when compared to usual care, it may slightly improve patient satisfaction and depression, and increase the chances of patients dying in their preferred place (measured by home death).
Researchers at Columbia University have developed AwareDX--Analysing Women At Risk for Experiencing Drug toXicity--a machine learning algorithm that identifies and predicts differences in adverse drug effects between men and women by analyzing 50 years' worth of reports in an FDA database. The algorithm, described September 22 in the journal Patterns, automatically corrects for the biases in these data that stem from an overrepresentation of male subjects in clinical research trials.
A new analysis of data from researchers at King's College London using information from the COVID Symptom Study app and patients admitted to St Thomas' Hospital in London, has shown that delirium - a state of acute confusion associated with a higher risk of serious illness and death - is a key symptom of COVID-19 in frail, older people.
In this randomized clinical trial, daily hydroxychloroquine didn't prevent SARS-CoV-2 infection among hospital-based health care workers, although the trial was terminated early.
A Phase 1 trial of an investigational mRNA vaccine to prevent SARS-CoV-2 infection has shown that the vaccine is well-tolerated and generates a strong immune response in older adults. A report published today in the New England Journal of Medicine describes the findings from the study, which was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. SARS-CoV-2 is the virus that causes COVID-19 disease.
Research findings published Aug. 14, 2020 in the journal Cancer Research suggest that since some cancer treatments can be undermined by epigenetic changes (altered DNA methylation affecting gene expression) in cancer cells before the treatments are even administered, a worthwhile strategy is to administer an epigenetically-acting drug - which can pave the way for more effective subsequent use of immune-acting cancer treatments.
A suite of new technologies enables researchers in Charleston, South Carolina, to remotely reach smokers throughout the state, allowing them to participate in clinical trials of investigational treatments that could help them quit.
In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway.Team now searching for a therapeutic that could block NFkB from unleashing unchecked inflammation at the onset of coronavirus infection.
A major national study led by experts from Bristol and Nottingham has found that oral antibiotics are just as effective as intravenous antibiotics in killing a common germ that causes dangerous complications in cystic fibrosis (CF) patients.
Approvals of prescription opioids by the U.S. Food and Drug Administration over more than two decades have been based on evaluations in narrowly defined patient groups for which certain safety-related outcomes have been rarely systematically assessed.