Researchers from NUS Yong Loo Lin School of Medicine's Infectious Diseases Translational Research Programme have discovered that the use of a common antibiotic, doxycycline, in combination with TB drug treatment, reduces the size of lung cavities and accelerates markers of lung recovery. This was done in a trial with 30 pulmonary tberculosis patients.
A population biobank study of 250,000 individuals in Finland -- Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes pain, swelling and stiffness in the joints. It can also cause fatigue, and the underlying inflammation may affect other body systems. Up to 10% of people with RA are affected by interstitial lung disease (ILD) during their lifetime, and ILD is one of the leading causes of death in patients with RA. Data presented at the 2021 EULAR congress report findings from a longitudinal study showing that people with MUC5B gene variant have a considerable lifetime risk of ILD, and that this gene variant contributes to increased morbidity. These findings have clinical implications for improving identification of people with RA who are at high risk for developing ILD.
A staged alert system, designed by scientists and public health officials to guide local policies, helped one city prevent hospital surges and long lockdowns, according to new research published in the journal Nature Communications.
Medical guidelines help doctors understand the best way to treat health conditions. Surprisingly, many doctors do not adhere to them, and this is a problem, according to a new study. People with lower back pain injury miss 11 more days of work in a year when they only receive treatments for lower back pain that are not recommended by medical guidelines compared to people treated according to guidelines.
New York City neighborhoods that had higher levels of socioeconomic disadvantage experienced more COVID-19 infections and deaths, according to Mount Sinai scientists who created a neighborhood-level COVID-19 inequity index.
1,660 routine diagnostic specimens that were collected at a Nottingham hospital between Jan. 2 and March 11, 2020, were retrospectively tested for SARS-CoV-2. Three people, who did not qualify for a PCR test for COVID-19 test at the time, were found to have the virus.
In 1943, two scientists named Max Delbrück and Salvador Luria conducted an experiment to show that bacteria can mutate randomly, independent of external stimulus, such as an antibiotic that threatens a bacterial cells' survival. Today the Luria-Delbrück experiment is widely used in laboratories for a different purpose--scientists use this classic experiment to determine microbial mutation rates.
A new model that applies artificial intelligence to carbohydrates improves the understanding of the infection process and could help predict which viruses are likely to spread from animals to humans. This is reported in a recent study led by researchers at the University of Gothenburg.
A review of more than 9,000 US patients with severe COVID-19 infection showed less than 1% contracted the illness again, with an average reinfection time of 3.5 months after an initial positive test. Those are the findings from a study conducted by researchers from the University of Missouri School of Medicine and MU Health Care.
A new antibody testing study examining samples originally collected through the National Institutes of Health's All of Us Research Program found evidence of SARS-CoV-2 infections in five states earlier than had initially been reported. These findings were published in the journal Clinical Infectious Diseases.