In a recently published study examining the effects of binge drinking on rats, researchers from the University of Missouri School of Medicine discovered that female rats who were of equal age and weight to male rats were more sensitive to alcohol and experienced alcoholic liver injury at a higher rate than male rats.
The liver plays a vital role as a filter in the body. But what happens when it malfunctions? Researchers (Switzerland) teamed up to perform a detailed analysis of hepatic encephalopathy. The scientists were able to observe for the first time in a mouse model that a dysfunction of the liver provokes cerebral molecular disturbances in two weeks, even though no physical symptoms are apparent. Moreover, several molecules are concerned, including two that were previously unknown.
Children with Inflammatory Bowel Disease (IBD) run a greater risk of psychiatric disorders, according to a new study from Karolinska Institutet in Sweden published in JAMA Pediatrics. The researchers claim that more psychological support and longer follow-up is needed for the children affected and their parents.
A Montreal hospital moved from an older facility with ward-type rooms to a new facility with all private rooms and this analysis examined whether that was associated with reductions in multidrug-resistant organism colonization and health care-associated infections.
Data from Swedish national registers were used to examine the risk of psychiatric disorders and suicide attempt in individuals diagnosed as children with inflammatory bowel disease (IBD) compared with people in the general population and with siblings of patients with IBD.
A new study from Washington University School of Medicine in St. Louis supports evidence that children with mild asthma can effectively manage the condition by using their two inhalers -- one a steroid and the other a bronchodilator -- when symptoms occur. This is in contrast to the traditional method of using the steroid daily, regardless of symptoms, and the bronchodilator when symptoms occur. The as-needed use of both inhalers is just as effective for mild asthma as the traditional protocol, according to the investigators.
Sticky meshworks of DNA and proteins extruded by white blood cells called neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation, researchers in Germany report Aug. 15, 2019 in the journal Immunity. Both genetic and pharmacological approaches that inhibited the formation of these so-called neutrophil extracellular traps (NETs) reduced the formation and growth of gallstones in mice.
A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases. Pankaj Kapahi of Buck Institute and colleagues report these findings in a new study published August 15, 2019 in PLOS Genetics.
Bacteria, like people, have complicated relationships. A group of researchers was able to engineer the genomes of 4 species of gut bacteria to make them rely on each other for essential nutrients rather than competing for them, and the whole community was stronger and more balanced as a result. This technology could enable bacteria-based therapies and tools that could be used to improve human health, produce valuable substances, or repair microbial ecosystems.
A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir -- a commonly prescribed topical herpes medication -- with particles of activated carbon improves efficacy of the drug.