A signaling protein thought to be able to treat liver damage in paracetamol toxicity could actually worsen it. Instead, Singapore scientists discovered, blocking its effects could be the way forward.
A rare parasitic infection imported from Europe continues to take root in Alberta. The province is now the North American hotspot for human alveolar echinococcosis (AE), which takes the form of a growth in the liver, causing serious and potentially deadly health complications.
Researchers from Osaka University, along with international collaborators in Europe, have identified Thrombospondin-2 as a serum biomarker that confirms and stratifies the progressive complications of nonalcoholic fatty liver disease. This research may form the basis of a new noninvasive approach that can provide an early warning system for nonalcoholic steatohepatitis and advanced fibrosis and may predict progression to cirrhosis, liver failure and even cancer.
Rising numbers of liver cancer in Aboriginal and Torres Strait Islander communities has led experts at Flinders University to call for more programs, including mobile liver clinics and ultrasound in rural and remote Australia. The Australian study just published in international Lancet journal EClinicalMedicine reveals the survival difference was largely accounted for by factors other than Indigenous status - including rurality, comorbidity burden and lack of curative therapy.
Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis.
New treatment combination for hepatitis C virus (HCV) is an additional affordable option for millions still waiting for access to lifesaving treatments in middle-income countries. Combination is safe and effective, including for hard-to-treat cases and people with HCV and HIV. New drug ravidasvir is the first HCV drug to be developed through South-South collaboration and with support from non-profit organizations.
Medical University of South Carolina researchers have discovered a gatekeeper protein that destines developing cells in an embryo to become liver cells. It exposes the genetic material of the cells and marks them as 'ready' for differentiation, i.e., transformation into liver cells, when developmental conditions are right. The findings, published in Cell Reports, could help scientists to better understand why liver cells do not develop correctly in children with inherited liver diseases.
In a subset of patients with partial lipodystrophy and/or NASH, the hormone leptin can be leveraged as a therapeutic agent to move fat out of the liver.
People who use methamphetamine are more likely to have health conditions, mental illness, and substance use disorders than people who do not use the drug, according to a new study by researchers at the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU School of Global Public Health.