An article in Cell shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
A standardized "Artificial Pancreas (AP) Dashboard" should provide easy to use single-page hybrid closed-loop system (HCL) reporting for insulin requiring patients with diabetes. The AP Dashboard will help standardize HCL reporting similar to standardized CGM reporting and an electrocardiogram (EKG) and will be likely to help improve glycemic control and reduce hypoglycemia.
Public health services across the world are failing to meet targets to reduce avoidable sight loss, according to a new study published today (1 December) in The Lancet Global Health.
Results of standard laboratory tests performed on adult outpatients to provide an overall picture of their health are fairly consistent between those with obesity and their leaner counterparts, investigators report.
Healthy cells and cells with Type 2 diabetes use completely different pathways to manage blood sugar levels, according to results from a study in mice. Researchers used a trans-omic approach, combining data from genes (transcriptomics) and metabolites (metabolomics) to identify and connect the many separate processes involved in responding to glucose. Obese mice lack most of the rapid response to glucose found in healthy metabolism, instead relying on much slower methods like changing gene expression.
A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine.
Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women.
Researchers at the University of Tsukuba used a cocktail of antibiotics to deplete gut microbes in mice. They found that metabolites in the gut differed in these mice compared with controls. In particular, metabolic pathways involved in making important neurotransmitters like serotonin were affected. Additionally, these mice showed abnormal day-night distribution in sleep/wake patterns, particularly the amount of REM sleep, and frequent transitions between REM and non-REM sleep episodes.
The combination of mild electrical stimulation and heat shock at 42 °C (MES+HS) exerts anti-inflammatory and anti-fibrotic effects in a mouse model of nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells. Clinical data have shown that the medical device used for this therapeutic approach is safe in humans. Researchers believe that it can be applied clinically to control the pathologies of NS.
Men with muscles like a young Arnold Schwarzenegger look powerful but a handshake will give away whether they're a healthy specimen - or at risk of a chronic disease or premature ageing, experts say. Medical researchers in South Australia assessed more than 600 men aged over 40 to 88 years in the Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study to measure the link between sleep apnea and muscle mass with grip strength.