Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias? A new study suggests the answer is no. If this is borne out, that result differs from Alzheimer's disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease -- and thus suggests that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer's disease.
A new scientific study published in Nature Catalysis shows that baker's yeast can be designed and optimised to produce polyamines and polyamine analogues for tackling grand challenges in both the health and agricultural sector.
Biologists from the Plant Physiology Laboratory at the University of Guam and neuroscientists from the Experimental Medicine Program at The University of British Columbia have published an update on the reputed environmental toxins that have been suspected of being involved in mammal neurodegeneration.
Scientists have long known the brain's hippocampus is crucial for long-term memory. Now a new Northwestern Medicine study has found the hippocampus also plays a role in short-term memory and helps guide decision-making. The findings shed light on how the hippocampus contributes to memory and exploration, potentially leading to therapies that restore hippocampal function, which is impacted in memory-related aging and neurodegenerative diseases such as dementia, the study authors said.
A study led by researchers from IBEC and IDIBAPS achieves, for the first time, the control of brain state transitions using a molecule responsive to light, named PAI. The results not only pave the way to act on the brain patterns activity and to understand their connection to cognition and behavior, but they also could lead to the development of photomodulated drugs for the treatment of brain lesions or diseases such as depression, bipolar disorders or Parkinson's or Alzheimer's diseases.
Scientists from The University of Texas Health Science Center at San Antonio and collaborating institutions found no associations of depressive symptoms with amyloid beta protein deposition in a study of middle-aged Framingham Heart Study participants. They did, however, note an association of tau protein aggregates with depressive symptoms in subjects carrying a genetic variant called APOE e4.
Despite near unanimous objection from its advisory panel, the US Food and Drug Administration (FDA) granted aducanumab approval to treat Alzheimer's disease on June 7, 2021. In a commentary published in Annals of Internal Medicine, a member and former Chair of the advisory panel and an aducanumab site investigator explain why this unprecedented "accelerated approval" is problematic for clinical research and patient care.
Case Western Reserve University researchers studying prions--misfolded proteins that cause lethal incurable diseases--have identified for the first time surface features of human prions responsible for their replication in the brain.
A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer's disease.
Chatbots hold promise for dementia patient or caregiver support, but are still in their infancy, finds a new paper. None of the interactive digital apps tested performed well on all testing criteria, and all the apps contained linguistic biases and usability challenges. The authors conclude that until developers produce evidence-based chatbots that have undergone end user evaluation it will be hard to evaluate their potential to adequately educate and support dementia patients and their caregivers.