A decade-long study of distal radius fracture revealed that personalized medicine catering to a patient's individual needs and environment, not age or X-rays, should guide treatment options. This federally funded study is the most intense, collaborative effort to answer a 200-year puzzle about how to treat the most common forearm fracture in older adults.
Medical guidelines help doctors understand the best way to treat health conditions. Surprisingly, many doctors do not adhere to them, and this is a problem, according to a new study. People with lower back pain injury miss 11 more days of work in a year when they only receive treatments for lower back pain that are not recommended by medical guidelines compared to people treated according to guidelines.
3D models of bone formation provide a tool for tissue engineering, biomedical research and drug testing.
In recent years, significant progress has been made towards the use of high-resolution peripheral computed tomography (HR-pQCT) imaging in research, and new potential for applications in the clinic have emerged. This new publication by the Joint IOF-ASBMR-ECTS HR-pQCT Working Group provides an important overview of current clinical applications of HR-pQCT in adults, valuable guidance on interpretation of results, and a summary of novel applications and future directions.
Researchers from University of Tsukuba, in collaboration with scientists in Germany, have created a mouse model of restrictive cardiomyopathy, a disease in which the heart muscle becomes stiff and the heart is unable to properly fill with blood. Their data suggest that the disease results from the accumulation of mutant BAG3 protein, which interferes with the protein quality control system and the machinery for breaking down and recycling damaged proteins, disrupting the heart muscle components.
Osteoporosis researchers at the UVA School of Medicine have taken a new approach to understanding how our genes determine the strength of our bones, allowing them to identify several genes not previously known to influence bone density and, ultimately, our risk of fracture.
The information presented in this study is primarily positioned to benefit scientists and experts in Cellular Physiology and Histochemistry where new tools to discover therapeutic targets for muscle atrophy are needed. The study outlines the development of a new fluorescent reporter mouse line to detect changes in mitophagy activity. These findings could revolutionize treatment strategies and possibly facilitate interventions to reverse disuse-induced muscle atrophy.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen provide better pain control and have fewer adverse effects than codeine, a commonly prescribed opioid, when prescribed after outpatient surgery, according to new research published in CMAJ (Canadian Medical Association Journal).
What The Study Did: This autopsy study examines differences in skeletal muscle and myocardial inflammation in patients who died with COVID-19 versus other diseases.
Researchers at Michigan Medicine found people with cerebral palsy have fragile bones that present high fracture risk, but at different times across the lifespan compared to the general population. The results helped them develop new sex-specific critical periods of bone health for this population.