A study published in the advanced edition of April 12, 2019 in the journal Neural Computation shows that approaches based on Long Short-Term Memory decoders could provide better algorithms for neuroprostheses that employ Brain-Machine Interfaces to restore movement in patients with severe neuromotor disabilities.
In the first study of its kind involving Duchenne muscular dystrophy (DMD) in the US, researchers from the Deerfield Institute found that while the number of new cases has remained stable, there has been an uptick in prevalence -- largely attributed to enhanced treatments and longevity.
Glucocorticoid use, especially with dosages above 10 mg/d, was associated with greater risk for adverse events among patients with rheumatoid arthritis (RA) undergoing joint replacement surgery. Risk for hospitalized infection, prosthetic joint infection, and readmission were similar across biologics. Findings from a cohort study are published in Annals of Internal Medicine.
A new special edition of 'Calcified Tissue International' provides expert commentary and insight into the advances in the knowledge of several rare focal and sclerotic bone diseases including Paget's disease of bone and related syndromes, fibrous dysplasia of bone and McCune-Albright syndrome, Melorheostosis and Osteopoikilosis, chronic non-bacterial osteomyelitis, as well as Camurati-Engelmann disease.
In healthy people, a tightly controlled process balances out the activity of osteoblasts, which build bone, and osteoclasts, which break it down. Damage to cells' mitochondria can make that process go awry, according to research led by University of Pennsylvania researchers. The findings shed light on how exposure to cigarette smoke, alcohol, and certain medications and environmental toxins can raise the risk of osteoporosis.
A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology.
Researchers report that a protein known to be important to protein synthesis also influences muscle regeneration and regrowth in an unexpected manner. The discovery, along with the identification of an inhibitor that blocks its effects, could one day lead to new methods for treating disorders that result in muscle weakness and loss of muscle mass, the researchers said.
How do bones heal, and how could they heal better? The answer to these questions may lie in a newly discovered population of 'messenger' cells, according to a recent USC Stem Cell study published in the journal eLife.
Researchers found more than 100 new genes that could lead to the development of cleft lip and palates. The team discovered that genetic variants near these genes are in regions of the genome called enhancers, which regulate expression of genes to maintain proper cell identity.
In a new study, scientists in pathology and anatomical sciences in the University of Missouri's School of Medicine have revealed a three-dimensional view of the skeletal muscles responsible for flight in a European starling. The study will form the basis of future research on the bird's wishbone, which is supported by these particular muscles and is hypothesized to bend during flight.