Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 antibody atezolizumab in patients with high-risk, HER2-positive early breast cancer.
The 'Xpert Ultra' molecular test has a greater capacity than its predecessor ('Xpert MTB/RIF') in detecting tuberculosis cases, either passively (i.e. people who attend the hospital with disease symptoms) or actively (searching for possible cases in the community among contacts of cases).
New York City neighborhoods that had higher levels of socioeconomic disadvantage experienced more COVID-19 infections and deaths, according to Mount Sinai scientists who created a neighborhood-level COVID-19 inequity index.
If Black patients were admitted to the same hospitals that serve a majority of White patients, researchers showed that their risk of death would drop by 10 percent.
When delivering moms require caesarians or their newborns need neonatal care, some families may spend as much as $10,000 out-of-pocket, according to a new Michigan Medicine-led study.
The fast-food industry spent $5 billion on advertising in 2019, and the advertisements disproportionately targeted Black and Hispanic youth, according to new research published today by the Rudd Center for Food Policy and Obesity at the University of Connecticut. The new report, Fast Food FACTS 2021, finds that the industry's annual ad spending in 2019 increased by over $400 million since 2012, and that children and teens were viewing on average more than two fast food TV ads per day.
Inhibiting necroptosis, a form of cell death, could yield a new treatment approach for chronic obstructive pulmonary disease (COPD), an inflammatory lung condition also known as emphysema, new research shows. The study, by a team of Australian and Belgian researchers, revealed elevated levels of necroptosis in patients with COPD. By inhibiting necroptosis activity in the lung tissue of COPD patients the researchers found a significant reduction in chronic airway inflammation and lung damage.
Scientists are already preparing for a possible next coronavirus pandemic to strike, keeping with the seven-year pattern since 2004. In future-looking research, scientists have identified a novel target for a drug to treat SARS-CoV-2 that also could impact a new emerging coronavirus. "God forbid we need this, but we will be ready," said the lead Northwestern scientist.
New study results indicate that different comorbid conditions affecting individuals diagnosed with COVID-19 may impact how long they continue to receive positive SARS-CoV-2 polymerase chain reaction (PCR) test results.
A study of young immigrant mothers who are survivors of sex trafficking found that the trauma affected how they parented: it made them overprotective parents in a world perceived to be unsafe, it fueled emotional withdrawal when struggling with stress and mental health symptoms, and was a barrier to building confidence as mothers. Yet, they coped with such challenges finding meaning in the birth of their child and through social support and faith.