A new Florida State University College of Medicine study in mice produced results that suggest nicotine exposure in men could lead to cognitive deficits in their children and grandchildren. Further studies will be required to know if the same outcomes seen in mice would apply to humans.
Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists at Goethe University have now been able to discover how these enzymes interact with each other. This brings them one step closer to their goal of engineering the production of such peptide natural products.
In the ongoing chemical battles among bacteria and their microbial neighbors, a new toxin has been uncovered. This unfamiliar toxin behaves in a familiar way. Its actions against other bacteria resemble the mechanisms of cholera, pertussis and diphtheria toxins. Some bacteria deploying this toxin have safeguards against self-poisoning.
Girls who play video games are three times more likely to choose physical science, technology, engineering or maths (PSTEM) degrees compared to their non-gaming counterparts, according to new research from the University of Surrey.
New study shows that some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA using a ribonucleotide reductase enzyme that does not require a metal ion cofactor.
Water-soluble protein helps to understand the photosynthetic apparatus.
Autologous blood doping, in which an athlete is transfused with their own stored red blood cells to increase their oxygen capacity for competition, might be detectable now with the use of a microRNA marker of blood aging. An 18-nucleotide miRNA called miR-720 is produced in a predictable pattern as blood ages, which would allow sports officials to detect this kind of blood doping for the first time. The finding might also improve blood storage.
Researchers have for the first time been able to investigate the abundance and methyl modifications of all mitochondrial tRNAs in patients suffering from one of the most common inherited mitochondrial tRNA mutations. The analysis pipeline revealed quantitative changes that had dramatic effects on protein synthesis within mitochondria.
Bacteria and Archaea have developed many types of CRISPR-Cas systems to protect themselves from viruses. A search through metagenomic databases of microbes, many of them uncultivatable, unearthed the genes of the smallest known working Cas complex, Cas14, from the genome of a DPANN Archaea, a group of microbes with the smallest known geomes. Cas14 is being incorporated into a CRISPR diagnostic called DETECTR.
A new molecular engineering technique has the potential to double the number of light-sensitive proteins available for studying brain circuits.