Experiments with rats indicate that brain cells submitted to several forms of hypoxia underwent alterations to their energy production mechanism. Such condition may affect the fetus in pregnant women who have developed pre-eclampsia.
To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive. Research from the National Institute of Standards and Technology (NIST) points to a weakness of previous testing and evaluation methods and provides a new hormone testing regime that offers better results.
Using a mixture of oil droplets and hydrogel, medical active agents can be not only precisely dosed, but also continuously administered over periods of up to several days. The active agents inside the droplets are released at a constant rate, decreasing the risk of over- or underdosage.
Scientists from Trinity College Dublin have made an important discovery with implications for those living with a common, debilitating eye disease (age-related macular degeneration, AMD) that can cause blindness. They have discovered that the molecule TLR2, which recognises chemical patterns associated with infection in the body, also seems to play an important role in the development of retinal degeneration. When TLR2 is removed in model systems, a degree of protection is conferred.
A team of researchers has verified that it is possible to engineer two-layered nanofibers consisting of an ordered row of alternating peptides, and has also determined what makes these peptides automatically assemble into this pattern. The fundamental discovery raises the possibility of creating tailored "ABAB" peptide nanofibers with a variety of biomedical applications.
Applying bioinformatics to resolve biological problems. This is the objective of the research group of the University of Malaga "BI4NEXT", which, in one of its latest studies, developed in the Supercomputing and Bioinnovation Center (SCBI) based on biobank samples, has identified new biomarkers for the diagnosis, prognosis and even treatment of lung cancer.
RNA turnover in the nuclei of eukaryotic cells is controlled by the RNA exosome aided by numerous cofactors. Researchers at Aarhus University and Copenhagen University now show how two major nuclear exosome cofactors recognize their RNA targets to keep a clean nuclear environment. This is important for the health of our cells - and thus humans.
Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers by tricking the cancer cells to behave as if they were starving for their favorite food -- glucose. The researchers' findings were recently published in the Journal of Biological Chemistry and may pave the way for targeted cancer treatments with greater efficacy and less harmful side effects.
A sweeping new set of findings by Salk researchers reveals previously unknown details explaining why some neurons in bipolar patients swing between being overly or under excited. The researchers used experimental and computational techniques to describe how variations in potassium and sodium currents in the brain cells of people with bipolar disorder may help to further explain why some patients respond to lithium and others do not.
A simple, portable test that can detect the deadliest of the mushroom poisons in minutes has been developed by Agricultural Research Service (ARS) scientists. Eating toxic mushrooms causes more than 100 deaths a year, globally, and leaves thousands of people in need of urgent medical assistance. Amanitin is the class of mushroom toxins that cause the most serious issues.