Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the amyloid precursor protein (APP)-cleaving enzymes directly affect the formation of amyloid beta (Aβ) plaques, a neuropathological hallmark of AD.BACE1 mRNA level in AD subjects was significantly higher than those of healthy controls, whereas ADAM10 level was significantly lower in the AD subjects.
A new quantum algorithm has been implemented for quantum chemical calculations such as Full-CI on quantum computers without exponential/combinatorial explosion, giving exact solutions of Schroedinger Equations for atoms and molecules, for the first time.
Patients who died of IS the most common type of dementia was vascular dementia while those died from other causes were most often diagnosed with Alzheimer's dementia (AD). Patients who died from IS and were registered in Riksstroke had higher MMSE score compared to other groups. Patients who died from IS took more cardiovascular medications. There were no differences in the use of antipsychotics, antidepressants, acetylcholinesterase inhibitors, memantine, anxiolytics, or hypnotics between the groups.
S. aureus under the biofilm mode of growth is often related to several nosocomial infections, more frequently associated with indwelling medical devices (catheters, prostheses, portacaths or heart valves).The present paper will provide an overview on the activity and potential applications of RIP as biofilm inhibiting compound, useful in the management of S. aureus biofilm infections.
Nanomedicine is a field of science that employs materials in the nanometer scale.Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common disorders worldwide, becoming a serious economic burden and public health problem.In this review, we have highlighted the potential of lipid nanoparticles in reaching the brain, a challenging task in modern medicine.
Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application.This review presents an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery systems.
Vinorelbine bitartrate (VRL), a semi synthetic vinca alkaloid approved for breast cancer, has been proven to be beneficial as first line and subsequent therapies. However, its hydrophilic and thermo labile nature provides hindrance to oral clinical translation. The current work focused on the application of DOE a modern statistical optimization tool for the development and optimization of a solid lipid nanoparticle (SLN) formulation that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate (VRL) to a maximum extent without compromising integrity and anticancer activity of the drug.
Researchers have combined artificial neural networks with infrared thermal imaging to control and interpret chemical reactions with new precision and speed. Novel microreactors allow chemical discoveries to take place quickly and with far less environmental waste than standard large-scale reactions. The system can reduce the decision-making process about certain chemical manufacturing processes from one year to a matter of weeks, saving tons of chemical waste and energy in the process.
The human monoamine transporters (hMATs) primary including hSERT, hNET and hDAT are important targets for the treatment of depression and other behavioral disorders with more than the availability of 30 approved drugs.This paper is to review the recent progress in the binding mode and inhibitory mechanism of hMATs inhibitors with the central or allosteric binding sites, for the benefit of future hMATs inhibitor design and discovery.
Synthetic psychoactive drugs have become a serious public health threat in recent years. This is particularly true of the fentanyls, a large family of synthetic opioids, which can be up to 10,000 times more potent than morphine. Synthetic opioids are highly addictive and, because of their potency, often prove fatal: among the roughly 72,000 drug overdose deaths in the US in 2017, some 30,000 were related to synthetic opioids.