What happens to the nanoparticles when they are injected into the bloodstream, for example, to destroy solid tumours? With new results published in ACS Nano, researchers from Aarhus University are now ready to tackle such a challenging question using zebrafish embryos as a new study model in nanomedicine and nanotoxicology.
Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer.
Experts who study animal pheromones have traced the evolutionary origins of genes that allow mice, rats and other rodents to communicate through smell. The discovery is a clear example of how new genes can evolve through the random chance of molecular tinkering and may make identifying new pheromones easier in future studies. The results represent a genealogy for the exocrine-gland secreting peptide (ESP) gene family.
The virus that causes COVID-19 uses a clutch-like shifter to enable transcription of one RNA string into multiple proteins, and therein lies a vulnerability. A proof-of-concept study shows it's possible to eliminate that shifter with an RNA-binding compound linked to a 'trash this' signal.
Feeding rates of blue mussels slow down under ocean acidification conditions, and the cause may be the slowing beat of gill cilia, similar to a known response in human lung cells.
Abnormal α-synuclein aggregation has been implicated in several neurodegenerative diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether differences in the strains of α synuclein aggregates account for the different pathologies remained unclear. Researchers in Tokyo Metropolitan Institute of Medical Science (TMIMS) discovered a possible molecular mechanism to account for the different pathologies induced by different α synuclein strains.
Aza-steroids are important class of compounds because of their numerous biological activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids.
New research led by Flinders University has found a link between beta-blockers and survival outcomes in some breast cancer patients. Beta-blockers, commonly used to manage cardiovascular disease, were negatively associated with survival outcomes in patients with HER2 (Human Epidermal Growth Factor Receptor 2) positive advanced breast cancer, according to a new paper in the Frontiers In Oncology.
This review summarizes an overview of the synthesis and functionalisation of quinoline scaffolds in aqueous medium. This method may encourage researchers to adopt green chemistry and to apply these environmentally safe methods in designing important heterocyclic cores.
POSTECH research team develops innovative local anticancer immunotherapy technology using mussel protein.