Researchers at the University of Washington unveiled a new strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to the scaffold using light. Since the tether can also be cut by laser light, this method can create evolving patterns of signal proteins throughout a biomaterial scaffold to grow tissues made up of different types of cells.
Researchers at McMaster University have invented a stable, affordable way to store fragile vaccines for weeks at a time at temperatures up to 40C, opening the way for life-saving anti-viral vaccines to reach remote and impoverished regions of the world.
Medical University of South Carolina investigators have exploited a metabolic quirk of certain cancers known as glutamine addiction to identify a potential new therapy for esophageal cancer. After characterizing the pathway involved in cancer progression, they tested a new combination treatment in both cells and animal models, with promising results. The next step is to secure funding to bring the new combination regimen to clinical trial. Their findings are reported in Nature Communications.
The June issue of SLAS Technology features the article, 'Next Generation Compound Delivery to Support Miniaturized Biology,' which focuses on the challenges of changing the established screening paradigm to support the needs of modern drug discovery.
The June cover of SLAS Discovery features cover article 'A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction,' by Timothy M. Willson, Ph.D.
Cancerous tumors can be made to bioluminesce, like fireflies, according to the level of their glucose uptake, giving rise to a technique for quantifying metabolite absorption. The firefly imaging technique for sugar can be translated from cancer to many other metabolic diseases.
Imagine a technology that could target pesticides to treat specific spots deep within the soil, making them more effective at controlling infestations while limiting their toxicity to the environment. Researchers at the University of California San Diego and Case Western Reserve University have taken a step toward that goal. They discovered that a particular plant virus can deliver pesticide molecules deeper below the ground, targeting places normally beyond their reach.
Cells depend on a protein called Parkin, which is mutated in some forms of Parkinson's disease, to get rid of damaged mitochondria. Recent research shows that a protein called MITOL helps Parkin find its way to those mitochondria.
Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1's specific interactions in cancer.
A detailed new model of a bacterial secretion system provides directions for developing precisely targeted antibiotics.