Researchers develop a new method to isolate specific cells, and in the process find a more robust fluorescent protein.
Scientists at Rice's Center for Theoretical Biological Physics detail the structure of dumbbell-like sequences in DNA during interphase that suggest several unseen aspects of chromosome configuration and function.
Computer modeling of the COVID-19 virus on supercomputers showed that the spike protein visits an intermediate state before it can dock to the receptor protein on the host cell membrane. This intermediate state can be useful for drug targeting to prevent the spike protein to initiate viral infection. The initial findings, which showed the existence of an intermediate semi-open state of the spike protein, was published in the Journal of Chemical Physics.
The long-term potentiation (LTP) and long-term depression (LTD) of hippocampal excitatory synapse involved in learning and memory formation in brain have been separately explained, but the molecular mechanism has not been elucidated. The group focused on the competition of exocytosis and endocytosis of AMPA-type glutamate receptors dependent on the number of calcium ions that flow into the postsynaptic neurons, and demonstrated the comprehensive understanding of the LTP and LTD by a large-scale mathematical model simulation.
Purdue University innovators are taking cues from nature to develop 3D photodetectors for biomedical imaging. The Purdue researchers used some architectural features from spider webs to develop the technology.
A team of Duke researchers has found that transcription factors have a tendency to bind strongly to "mismatched" sections of DNA, i.e. sections of the genome that were not copied correctly. The strong binding of transcription factors to these mismatched sections of regulatory DNA might be a way in which random mutations become a problem that leads to disease, including cancer.
Converting heat into electricity is a property thought to be reserved only for stiff materials like crystals. However, researchers--inspired by the infrared (IR) vision of snakes--developed a mathematical model for converting soft, organic structures into so-called 'pyroelectric' materials. The study, appearing October 21, 2020 in the journal Matter, proves that soft matter can be transformed into a pyroelectric material and potentially solves a long-held mystery surrounding the mechanism of IR vision in snakes.
Decades-old data is being used to describe the propagation of tiny droplets. Now a fluid dynamics team has developed new models: Masks and distancing are good, but not enough. Even with a mask, infectious droplets can be transmitted over several meters and remain in the air longer than previously thought.
A team of researchers at Osaka University, in collaboration with the University of Bordeaux and the Bergonié Institute in France, has succeeded in terahertz imaging of early-stage breast cancer less than 0.5 mm without staining. Differences in terahertz intensity distributions also suggest the possibility of quantitative determination of cancer malignancy. Their work provides a breakthrough towards rapid and precise on-site diagnosis of various types of cancer and accelerates the development of innovative terahertz diagnostic devices.
Researchers at McMaster University and SQI Diagnostics in Canada have created a surface that repels every other element of human blood except an elusive cytokine critical to understanding the progress of COVID-19 in individual patients.