Researchers develop a new method to isolate specific cells, and in the process find a more robust fluorescent protein.
Moving around in the half-light is difficult but not impossible. To help us in this undertaking we have the rods, a type of photoreceptors present in the retina of vertebrates, capable of detecting very low lights. They are the protagonists of the new study published in PNAS by a team of researchers of SISSA and CNR-Iom which reveals new and essential details of how the retina works and in particular photoreceptors.
Recent successes of several FDA-approved therapeutic nucleic acids, together with the rapid preclinical progression of nucleic acid nanoparticles (NANPs), have made it apparent that immunological effects of NANPs must be carefully assessed to permit their successful clinical translation. Based on extensive studies, a standardized protocol allowing for the assessment of NANPs' pro-inflammatory properties in validated preclinical model, peripheral blood mononuclear cells, has been developed to be highly predictive of cytokine responses.
All biological processes are in some way pH-dependent. Our human bodies, and those of other organisms, need to maintain specific- and constant- pH regulation in order to function. Changes in pH can have serious biological consequences or, as researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS) found, serious benefits.
The Energy Futures Initiative (EFI) and Stanford University released "An Action Plan for Carbon Capture and Storage in California: Opportunities, Challenges, and Solutions," a report providing policymakers with options for near-term actions to deploy carbon capture and storage (CCS) to meet the state's climate goals.
Columbia Engineering researchers report their innovative robotic Trunk Support Trainer, when combined with active practice of postural movements, improves trunk and reaching control in CP children with impaired sitting control. TruST helps physical therapists to not only support the children in the region of the trunk where they suffer from weakness and incoordination but also challenge them to perform rehabilitation tasks outside their base of support to improve their movement and coordination.
One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D.
Specific regions in cord blood DNA can help identify kids who might develop autism, according to a UC Davis MIND Institute study. The findings from the study may hold clues for early autism diagnosis and intervention.
Researchers at the University of Rochester and the Fresnel Institute in France have found a way to visualize those molecules in even greater detail, showing their position and orientation in 3D, and even how they wobble and oscillate. This could shed invaluable insights into the biological processes involved, for example, when a cell and the proteins that regulate its functions react to a COVID-19 virus.
A team of Duke researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. This advance has enabled Duke and UNC virologists to watch the battle between the SARS-CoV-2 coronavirus and lung cells at the finest molecular scale. In experiments so far, the mini lungs respond just like the real thing.