In a large-animal study, researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cell line, or hiPSCs, that overexpress cyclin D2. This research, published in the journal Circulation, used a pig model of heart attacks, which more closely resembles the human heart in size and physiology, and thus has higher clinical relevance to human disease, compared to studies in mice.
Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The finding suggests that physicians could consider treating male patients with stomach inflammation differently than female patients with the same condition. The study was published in Gastroenterology.
Better designed vaccines for insect-spread viruses like dengue and Zika are likely after researchers discovered models of immature flavivirus particles were originally misinterpreted. Researchers from The University of Queensland and Monash University have now determined the first complete 3D molecular structure of the immature flavivirus, revealing an unexpected organization.
Kakshine is an entirely new DNA fluorescent imaging probe with a wide range of capabilities that make it ideal for a range of imaging applications, including cutting edge two-photon excitement imaging and super high-resolution STED imaging. Its ability to use low phototoxicity visible light makes it ideal for in vitro and in vivo applications, and it is expected to find use in a variety of medical and life science contexts.
Some nonpathogenic microorganisms can stimulate plant immune responses without damaging the plants, which allows them to act like plant vaccines, but screening microorganisms for such properties has traditionally been time-consuming and expensive. Now, a team of scientists from Tokyo University of Science has developed a screening method based on cultured plant cells that makes such testing easier. This may lead to microorganism-based crop protection methods that reduce the need for chemical pesticides.
Scientists show for the first time that the primary cilium - a sensing 'organ' of cells - helps the cells that form the lymphatic vessels of mammals to grow into a functional and locally responsive network, not only during prenatal development but also during inflammation and wound healing. This discovery, in a study by the open access publisher Frontiers, could inspire new medical therapies.
A family of proteins that sense mechanical force--and enable our sense of touch and many other important bodily functions--also are essential for proper root growth in some plants, according to a study led by scientists at Scripps Research and Howard Hughes Medical Institute.
In a study carried out in mice at the University of Chicago, researchers found that lasofoxifene outperformed fulvestrant, the current gold-standard drug, in reducing or preventing primary tumor growth.
According to data from a cohort of adult and pediatric patients with antibody deficiencies, patients that often fail to make protective immune responses to infections and vaccinations showed robust T-cell activity and humoral immunity against SARS-CoV-2 structural proteins. The new study, led by researchers at Children's National Hospital, is the first to demonstrate a robust T-cell response against SARS-CoV-2 in immunocompromised patients.
Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.