In a large-animal study, researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cell line, or hiPSCs, that overexpress cyclin D2. This research, published in the journal Circulation, used a pig model of heart attacks, which more closely resembles the human heart in size and physiology, and thus has higher clinical relevance to human disease, compared to studies in mice.
Mother fence lizards that experience stress during pregnancy give birth to male offspring with shortened telomeres, or bits of non-coding DNA that cap the ends of chromosomes, according to a Penn State-led study. Shorter telomeres are associated with decreased lifespan in humans; therefore, the team's findings may have implications for human longevity.
Scientists show for the first time that the primary cilium - a sensing 'organ' of cells - helps the cells that form the lymphatic vessels of mammals to grow into a functional and locally responsive network, not only during prenatal development but also during inflammation and wound healing. This discovery, in a study by the open access publisher Frontiers, could inspire new medical therapies.
Australian researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells. The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an 'RNA atlas' that details the different cells found in these tissues.
Researchers from TMDU, collaborating with scientists from MBL and RIKEN, developed a new probe, POLArIS, for real-time live-cell imaging that reveals the orientation of molecules and is expected to be applicable to a wide range of cell types and specimens. They tested POLArIS in starfish early embryos and discovered the existence of a new F-actin cellular architecture, FLARE, extending alongside the astral microtubules to the cell cortex. This may provide answers to some of the most fundamental questions regarding cell division.
A person's stance on abortion is linked to their, often inaccurate, belief about when a fetus can feel pain, a University of Otago study has found.
Higher levels of ozone from air pollution are linked to an increased risk of developing fibroids among Black American women according to a large study published in Human Reproduction. This is the first study to look at the link between fibroids in Black women and air pollution.
Scientists help protect sharks by developing aquarium breeding programs that pair up individuals in ways that increase genetic diversity. In a new study in Scientific Reports, scientists undertook the largest-ever effort to artificially inseminate sharks.Their work resulted in 97 new baby sharks, including ones whose parents live on opposite sides of the country and a few that don't have fathers at all.
Research published in Nature reveals insights into how the body maintains balance with "good" gut bacteria that allows these microbes to flourish in the intestine but keeps them out of tissues and organs where they're not supposed to be.
Brown bears that are more inclined to grate and rub against trees have more offspring and more mates, according to a University of Alberta study. The results suggest there might be a fitness component to the poorly understood behaviour.