A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences--and a better understanding of how evolution moves forward.
'A study like this makes it clear that even though we may think we know everything there is to know about the opioid response, we're actually just scratching the surface.' -- Kirill Martemyanov, PhD, Scripps Research Neuroscience Co-Chair
An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments. The study, published in Science Advances, compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness.
The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments.
Researchers have uncovered an unusual protein activity in rice that can be exploited to give crops an edge in the evolutionary arms race against rice blast disease, a major threat to rice production around the world.
In a paper published August 15 in the journal Neuron, the researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.
A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases. Pankaj Kapahi of Buck Institute and colleagues report these findings in a new study published August 15, 2019 in PLOS Genetics.
Bacteria, like people, have complicated relationships. A group of researchers was able to engineer the genomes of 4 species of gut bacteria to make them rely on each other for essential nutrients rather than competing for them, and the whole community was stronger and more balanced as a result. This technology could enable bacteria-based therapies and tools that could be used to improve human health, produce valuable substances, or repair microbial ecosystems.
Researchers have developed a guide to help labs standardize the production of mature hepatic-like cells (HPCs) from stem cells and easily compare gene expression of HPCs to actual human liver tissue.
An optimized and newly engineered form of the adeno-associated vector 9 (AAV9) vec-tor used to deliver the galactosylceramidase gene to a mouse model of the inherited neu-rogenerative and rapidly fatal form of Krabbe disease improved clinical symptoms and prolonged median survival by 275%.