The study suggests that the SWI/SNF complex may be a tumour suppressor and DNA-RNA hybrids could be an important source of tumour generation
Researchers from Tokyo Medical and Dental University (TMDU) have demonstrated that delivering oxygen via the rectum as a gas or in an oxygen-rich liquid can support oxygen provision to organs and tissues during respiratory failure. Such "enteral ventilation" increased oxygenation, improved behavior and prolonged survival in experimental mouse and pig models of respiratory failure. Further research may allow its clinical application in human patients as a less invasive alternative to ventilators and artificial lungs.
Scientists from China have sequenced and analyzed the genome of lavender to provide insights into what causes its distinct aroma. Their findings shed light into the evolution of this uniquely fragrant plant, which could pave the way for creating improved lavender varieties besides adding to existing knowledge on the evolution, phytochemistry, and ecology of Lamiaceae, the plant family to which lavender belongs.
Research conducted by an international team of scientists discovered a mechanism that leads to Herceptin resistance, representing a significant clinical obstacle to successfully treating HER2-positive breast cancer. They also identified a new approach to potentially overcome it.
SARS-CoV-2 is critically dependent on a special mechanism for the production of its proteins. A collaborative team led by a research group at ETH Zurich obtained molecular insights into this process and demonstrated that it can be inhibited by chemical compounds, thereby significantly reducing viral replication in infected cells.
A new study's findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist's office.
A new strategy for capturing the 3D shape of the human face draws on data from sibling pairs and leads to identification of novel links between facial shape traits and specific locations within the human genome. Hanne Hoskens of the Department of Human Genetics at Katholieke Universiteit in Leuven, Belgium, and colleagues present these findings in the open-access journal PLOS Genetics.
Mutations in two genetic regions in dogs explain over one third of the risk of developing an aggressive form of hematological cancer, according to a study led by Jacquelyn Evans and Elaine Ostrander at the National Human Genome Research Institute in Maryland, USA and colleagues. The study, which combined multiple sequencing techniques to investigate histiocytic sarcoma in retriever dogs, publishes May 13 in the open-access journal PLOS Genetics.
A new whole genome sequence for the Yap hadal snailfish provides insights into how the unusual fish survives in some of the deepest parts of the ocean. Xinhua Chen of the Fujian Agriculture and Forestry University and Qiong Shi of the BGI Academy of Marine Sciences published their analysis of the new genome May 13th in the journal PLOS Genetics.
Scientists use a swathe of modern techniques to map, in unprecedented detail, the molecular changes in the brain of mice that grew up in stimulating surroundings. These can be pinpointed to specific 'epigenetic' modifications to the genome within neurons and glia cells. These then regulate the activity of a minority of genes, especially within genomic regions implicated in cognitive mental health in humans. Published by the open access publisher Frontiers, the study may yield new leads in the search for mental health therapies.