A large international team has produced the largest map of interactions between gene-encoded protein molecules. A decade in the making, the map has the power to reveal the function of lesser-studied human proteins as well as the molecular causes of disease.
In contrast with China and other countries where the disease spread slowly, in Brazil more than 300 people started the epidemic. Most were passengers flying in from Italy.
From early prenatal development through childhood, the prefrontal cortex of the human brain undergoes an avalanche of developmental activity. In some cases, it also contains seeds of neuropsychiatric illnesses such as autism spectrum disorder and schizophrenia, according to a new genetic analysis led by researchers at Yale University and the University of California-San Francisco.
In the plant sciences, CRISPR--the bacterial gene editing toolbox that enables more precise and efficient editing of genomic sequences than previously possible--has initially been applied with genetic model organisms like Arabidopsis thaliana. While these species are valuable, they represent only a small sample of plant diversity. Researchers at the University of Florida, Gainesville, review the prospects for expanding CRISPR use in nongenetic model plant species, many of which are economically and biologically important.
Clemson University researchers have conducted a study that may someday lead to better cavity prevention measures and treatments. The team examined the oral mycobiome by taking a site-specific approach -- looking at both tooth and mouth health -- which enabled them to categorize each plaque sample along a continuum. They identified 139 species of fungus that live in human dental plaque, including nine that were strongly associated with dental health.
Researchers from the Center for Precision Disease Modeling at the University of Maryland School of Medicine (UMSOM) have uncovered a mechanism that appears to explain how certain genetic mutations give rise to a rare genetic kidney disorder called nephrotic syndrome.
Live, single-cell imaging shows cellular 'memory' of growth factor availability throughout the cell cycle (and not just snapshot of growth factor availability) influences cells' decision to replicate.
Researchers from King's College London have shown that how we respond to changes in nutrients at a molecular level plays an important role in the aging process, and this is directed by some key genetic mechanisms.
The DNA sequencing of a healthy German shepherd offers scientists new insight into the evolution of the domestic dog while also enabling dogs to be screened for hip and other diseases much more accurately.
Collaboration co-led by researchers at St. Jude Children's Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma.