Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. The treatment does not harm these humanized cells.
When the cells stop dividing, the centrioles migrate to the plasma membrane and allow the formation of primary and mobile cilia, which are used for the transfer of information and the genesis of movement. While performing these biological functions, centrioles are therefore subjected to many physical forces, which they must resist. Scientists (UNIGE) have discovered an internal structure at the center of these nano-cylinders, a cellular scaffolding that maintains the physical integrity of this organelle.
RNA turnover in the nuclei of eukaryotic cells is controlled by the RNA exosome aided by numerous cofactors. Researchers at Aarhus University and Copenhagen University now show how two major nuclear exosome cofactors recognize their RNA targets to keep a clean nuclear environment. This is important for the health of our cells - and thus humans.
Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models.
New research from the UBC's Okanagan campus, Harvard Medical School and Michigan State University suggests that levitating human plasma may lead to faster, more reliable, portable and simpler disease detection. The researchers used a stream of electricity that acted like a magnet and separated protein from blood plasma. Plasma is the clear, liquid portion of blood that remains after red blood cells, white blood cells, platelets and other cellular components are removed.
Fresh produce is a major vehicle for noroviruses, a group of viruses that are the most common cause of gastroenteritis in developed countries. However, the viruses are quite resistant to cold pasteurization treatments such as irradiation, which are used to destroy bacteria, moulds, parasites, and insects. The irradiation process uses gamma rays or X-rays to destroy these viruses but at the dose needed to eliminate them, it can affect the physicochemical properties of fresh produce.
A new Tel Aviv University study identifies the precise receptor chain involved in the development of atopic dermatitis, the most common cause of eczema. The researchers hope to develop an antibody based on this research to create a therapeutic drug.
EPO, an important drug for treating anemia, can now be produced in higher quantities and with better quality in mammalian cells designed using CRISPR.
Ecological niches are a concept well known from higher animals. Apparently, bacteria act accordingly. Researchers from the Max-Planck-Institute for Marine Microbiology in Bremen have found that marine Polaribacter bacteria find their ecological niche by specializing on their favorite sugar. They now present their results in ISME Journal.
The microbiome of our ancestors might have been more important for human evolution than previously thought. By comparing data from prior studies, the authors revealed that an adaptive gut microbiome could have been critical for human dispersal, allowing our ancestors to survive in new geographic areas.