A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published today in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, it can prevent the cancer from being recognized and destroyed by the immune system.
Bacteria do not simply perish in hunger phases fortuitously; rather, the surrounding cells have a say as well. A research team from the Technical University of Munich (TUM) has now discovered that two factors, above all, decide over life and death: the energy required to continue living and the efficiency with which surviving cells can recycle biomass from dead cells.
St. Jude investigators have discovered an association between a deficiency in the enzyme neuraminidase 1 and the build-up of connective tissue in organs, suck as the muscle, kidney, liver, heart and lungs.
Two newly discovered organisms point to the existence of an ancient organism that resembled a tiny version of the lumbering, human-eating science fiction plants known as 'triffids,' according to research in Nature.
Antibiotics combat bacterial infections, but the battle is becoming increasingly more difficult. The use of antibiotics in hospitals, in plant protection products or in livestock farming has the result that bacteria begin to defend themselves and build up more and more resistance -- even to reserve drugs.
London's house sparrows (Passer domesticus) have plummeted by 71% since 1995, with new research suggesting avian malaria could be to blame.
Gut microbes produce compounds that prime immune cells to destroy harmful viruses in the brain and nervous system, according to a mouse study published today in eLife.
Studying the association between diet quality and microbiome composition in human colonic mucosa revealed that a high-quality diet is linked to more potentially beneficial bacteria, while a low-quality diet is associated with an increase in potentially harmful bacteria.
Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude scientists have determined at atomic resolution the structure of machinery that drives the process.
Scientists at the University of Kent have developed a new method of determining gene function in a breakthrough that could have major implications for our understanding of the processes of life.