Researchers at the University of Washington unveiled a new strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to the scaffold using light. Since the tether can also be cut by laser light, this method can create evolving patterns of signal proteins throughout a biomaterial scaffold to grow tissues made up of different types of cells.
Scientists have identified a new mechanism that accelerates aging in the brain and gives rise to the most devastating biological features of Alzheimer's disease. The findings also unify three long-standing theories behind the disease's origins into one cohesive narrative that explains how healthy cells become sick and gives scientists new avenues for screening compounds designed to slow or stop disease progression, something existing medications cannot do.
Medical University of South Carolina investigators have exploited a metabolic quirk of certain cancers known as glutamine addiction to identify a potential new therapy for esophageal cancer. After characterizing the pathway involved in cancer progression, they tested a new combination treatment in both cells and animal models, with promising results. The next step is to secure funding to bring the new combination regimen to clinical trial. Their findings are reported in Nature Communications.
The June cover of SLAS Discovery features cover article 'A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction,' by Timothy M. Willson, Ph.D.
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have used CRISPR technology to probe the mechanisms that guide the developmental trajectories of stem cells in the brain. The results show that crucial cellular switches are doubly protected against unintended activation.
Many patients with chronic illnesses such as AIDS, cancer, autoimmune diseases, suffer from an additional disease called cachexia. The complex, still poorly understood syndrome, with uncontrollable weight loss and shrinkage of both fat reserves and muscle tissue is thought to contribute to premature death. Researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences describe the molecular mechanisms of cachexia during viral infection and identify a surprising role for immune cells.
Cells depend on a protein called Parkin, which is mutated in some forms of Parkinson's disease, to get rid of damaged mitochondria. Recent research shows that a protein called MITOL helps Parkin find its way to those mitochondria.
A detailed new model of a bacterial secretion system provides directions for developing precisely targeted antibiotics.
For the first time, immunologists have captured on video what happens when T cells undergo a type of assassin-training program before they get unleashed in the body. A new imaging technique that allowed for the videos, described today in the journal Nature Communications, holds promise for the fight against autoimmune disorders such as Type 1 diabetes.