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High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a potentially fatal disease caused by obstruction of blood flow in the lungs. A new study in The American Journal of Pathology, published by Elsevier, sheds light on the pathology underlying PAH and shows that dofetilide, an FDA-approved KV11.1 channel blocker for the treatment of cardiac arrhythmias (brand name: Tikosyn), may be used for treatment of PAH.
Australian researchers are making major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.
New research from La Trobe University suggests there is no evidence that changing a runner's strike pattern will help prevent injuries or give them a speed boost.
In a new review paper, MIT neuroscientists lay out the the few knowns and many unknowns that must be understood to determine why sensory stimuluation of 40Hz brain rhythms have broad effects, particularly in Alzheimer's models.
New research published today in The Journal of Physiology shows that breastfeeding is crucial in preventing diabetes.
As technology advances in the things we use every day, it's generally accepted they also become safer. But according to one UBC engineer, that may not be true for a large portion of the population. New research from UBC's Okanagan campus has developed a innovative model to map the impact of trauma on a pregnant woman and her uterus if she were involved in an accident--with the hopes of making everything from airbags to seatbelts safer for all.
New research from the University of Liverpool, presented at The Physiological Society's early career conference Future Physiology 2019 shows that after just two weeks of reduced physical activity (around 1,500 steps per day), older adults lose significant amounts of muscle which coincides with substantial gains in body fat percentage, especially around the waist.
A team led by Dr. Brigitte Gomperts at UCLA has developed a 'scar in a dish' model that uses multiple types of cells derived from human stem cells to closely mimic the progressive scarring that occurs in human organs. The researchers used this model to identify a drug candidate that stopped the progression of and even reversed fibrosis in animal models.
A German study finds that around 50 % of the population experience headache attributed to ingestion or inhalation of a cold stimulus (HICS), regardless of having the diagnosis of migraine or other primary headaches. HICS is a headache subtype, among dozens of types of headaches listed in the International Classification of Headaches Disorders. In spite of not being of concern as a health problem, this kind of headache may thief pleasure moments, for example, while enjoying a mouthful of ice cream.
A new mechanism that contributes to adult bone maintenance and repair opens the possibility of developing therapeutic strategies for improving bone healing.