MW189 blocks abnormal inflammation in the brain that is known to contribute to injury- and disease-induced neurologic impairments in a number of acute and chronic brain disorders. This study examining MW189 in healthy adult volunteers was performed by a collaborative team from UK, Duke University, and Northwestern University. The work by Van Eldik and the rest of the team is substantial as it is the first time MW189 had been tested in humans.
Researchers show that an oncogenic mutation in leukemia cells also promotes inflammations in the body
In a way, plants are energy wasters: in order to protect themselves from excessive electron transport, they continuously quench light energy and don't use it for photosynthesis and biomass production. A mutation can make them work more efficiently, as was discovered by a team from Ruhr-Universität Bochum (RUB) and Martin Luther University Halle-Wittenberg (MLU).
A large international team has produced the largest map of interactions between gene-encoded protein molecules. A decade in the making, the map has the power to reveal the function of lesser-studied human proteins as well as the molecular causes of disease.
Researchers from Cornell University have identified a possible target for antiviral treatment for COVID-19.
New understandings of how lipids function within tears could lead to better drugs for treating dry eye disease.
Ursolic acid, abundant in fruit peels and some herbs, both prevents and repairs neurons in animal models of multiple sclerosis.
A new therapy could combat persistent joint infections in horses, potentially saving them from years of pain. Morris Animal Foundation-funded researchers at North Carolina State University have developed a platelet-rich plasma (PRP) lysate that, when teamed with antibiotics, can eradicate bacterial biofilms common in joint infections. The therapy could also be applied to other species, including humans and dogs. The team presented their findings in the Journal of Orthopaedic Research.
Radiolabeled molecules help nuclear physicians to detect and precisely target tumors, which are often developing due to pathological changes in metabolic processes. Using positron emission tomography, scientists at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) have now developed the first radiotracer labelled with the fluorine isotope 18F, which can visualize special transport proteins often found in the cell membranes of cancer cells. The researchers opted for an unusual radiochemical synthesis approach, as they describe in the journal Scientific Reports.
The movements of cell muscles in the form of tiny filaments of proteins have been visualized at unprecedented detail by University of Warwick scientists.