MW189 blocks abnormal inflammation in the brain that is known to contribute to injury- and disease-induced neurologic impairments in a number of acute and chronic brain disorders. This study examining MW189 in healthy adult volunteers was performed by a collaborative team from UK, Duke University, and Northwestern University. The work by Van Eldik and the rest of the team is substantial as it is the first time MW189 had been tested in humans.
Approximately 5% of women experience two or more miscarriages, a condition known as recurrent pregnancy loss (RPL). Although genetic testing is important for evaluating RPL, current tests have revealed shortcomings in clinical practice. A report in The Journal of Molecular Diagnostics describes a new high-resolution melting analysis-based test that is accurate, rapid, cheap, and easy to perform. When used prior to other tests, it improved cost-effectiveness by 30%, an important consideration in areas with limited healthcare resources.
Plant-derived chemicals called cardenolides - like digitoxin - have long been used to treat heart disease, and have shown potential as cancer therapies. But the compounds are very toxic, making it difficult for doctors to prescribe a dose that works without harming the patient. Researchers now show that the wormseed wallflower could be used as a model species to elucidate how plants biosynthesize cardenolides, knowledge that could aid the discovery and development of safer drugs.
In this Ideas and Opinions piece from the University of California, San Francisco and San Francisco Veterans Affairs Medical Center, the authors discuss the findings of early studies that addressed the use of chest computed tomography for the detection of COVID-19. The authors urge caution in rushing science and overinterpreting preliminary or flawed data.
Hoping to refine the usefulness of RNA sequencing, a team of researchers reviewed a database of RNA sequencing results in non-clinically-accessible tissues from organs like the brain and heart. This helped them identify differences between tissues that were well expressed to help identify when clinically-accessible tissues like blood and skin samples are most useful and when they are not.
Researchers from North Carolina State University have developed an 'off-the-shelf' artificial cardiac patch that can deliver cardiac cell-derived healing factors directly to the site of heart attack injury.
UC San Diego scientists studying bacteria have identified the roots of a behavior that is regulated by the circadian clock. The research provides a striking example of the importance of keeping the internal biological clock aligned with the external environment so that key processes occur at the right time of day.
A new paper, ;COVID-19 in Humanitarian Settings and Lessons Learned from Past Epidemics' published in Nature Medicine, invokes a global response to protect the most vulnerable during the COVID-19 pandemic.
Medical marijuana users who say they have high levels of pain are more likely than those with low pain to say they use cannabis three or more times a day, a new study finds. However, daily marijuana users with severe pain also reported their health had become worse in the past year.
New research from McGill University has found that the presence and severity of mild behavioral impairment (MBI) in cognitively healthy individuals is strongly associated with the presence of amyloid plaques deposits in the brain, a hallmark of Alzheimer's disease.