Study uncovers key insights about how a new class of antiviral drugs works. Cryo-EM images showed the drugs bound to herpes simplex virus (HSV) protein at nearly atomic detail, while optical tweezers experiments showed how the drug-bound protein behaved in real time. Findings could open doors to additional drugs for herpesviruses and other DNA viruses.

A research team at Oregon Health & Science University has discovered a promising new drug combination that may help people with acute myeloid leukemia overcome resistance to one of the most common frontline therapies.

In a bid to improve end-of-life care for incarcerated individuals in the California prison system, UC San Francisco researchers have found a way to predict who is most likely to die within two years and should be considered for palliative care or compassionate early release. 

A team led by investigators at Mass General Brigham and Dana-Farber Cancer Institute has developed and validated an artificial intelligence (AI)–based noninvasive tool that can predict the likelihood that a patient’s oropharyngeal cancer—a type of head and neck cancer that develops in the throat—will spread, thereby signaling which patients should receive aggressive treatment. The research is published in Journal of Clinical Oncology.