Potential mechanisms (IMAGE)
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Potential mechanisms by which ribosomal protein gene (RPG) downregulation could affect synaptic inputs. Globally, RPG downregulation may result in decreased ribosome production, which may reduce synthesis of synaptic proteins, resulting in decreased synaptic weight overall. Locally, RPG downregulation may also change ribosome composition so that a few ribosomal proteins are either removed, altered, or replaced by other ribosomal proteins. These changes may result in the production of specialized ribosomes, which can alter synaptic protein translation in a cellular compartment-specific manner. Reduced ribosome production can accompany the production of specialized ribosomes, in which case reduced synaptic weight can also be observed locally.
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Zhang et al.
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