Study highlights the protective role of intestinal sulfated glycans in obesity and intestinal inflammation (IMAGE)

Chiba University

Study highlights the protective role of intestinal sulfated glycans in obesity and intestinal inflammation

Caption

 Chst4–/– mice lacking GlcNAc-6-O-sulfation of the mucin O-glycans showed significant weight gain, increased intestinal inflammation, and significantly reduced immunoglobulin A (IgA) production caused by an impaired T follicular helper cell-mediated IgA response. These phenotypes are dependent on the alteration of gut microbiota in the Chst4–/– mice.

Credit

Authors from Chiba University, Kyoto Prefectural University of Medicine, and Georgia State University https://insight.jci.org/articles/view/165944

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