De novo designed all-α proteins with complicated shapes. (IMAGE)

National Institutes of Natural Sciences

De novo designed all-α proteins with complicated shapes.

Caption

H5_fold-0_Chantal, H5_fold-0_Elsa, H6_fold-C_Rei, H6_fold-Z_Gogy, H6_fold-U_Nomur, and H7_fold-K_Mussoc are presented. For each de novo designed protein, the computational model is shown on the left, and the solved experimental structure is on the right.

Credit

Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Tatsumi-Koga & Nobuyasu Koga, “Design of complicated all-α protein structures”, Nature Structural and Molecular Biology (2024)

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CC BY

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