3-D structure of CBASS (IMAGE)

The Mount Sinai Hospital / Mount Sinai School of Medicine

3-D structure of CBASS

Caption

Icahn Mount Sinai researchers unveil how the self-killing activity of bacteria can be used in the fight against antibiotic resistance. Above: 3-D structure of CBASS Cap5 protein tetramer (shown in cyan) formed upon binding to the cyclic dinucleotide (shown in orange) to destroy bacteria’s own DNA (model, shown in red). Essential magnesium ions for DNA cleavage are shown in green.

Credit

Rechkoblit et al., Nature Structural & Molecular Biology

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