Regulation of ischemia-reperfusion injury through a bicarbonate-sensitive G protein-coupled receptor. (IMAGE)

Juntendo University Research Promotion Center

Regulation of ischemia-reperfusion injury through a bicarbonate-sensitive G protein-coupled receptor.

Caption

GPR30 in brain microvasculature responds to bicarbonate, and its deficiency protects against ischemia-reperfusion injury, reducing neurological deficits and blood-brain barrier disruption. These findings offer insights into developing innovative clinical approaches for ischemic stroke.

Credit

Dr. Airi Jo-Watanabe of Juntendo University Graduate School of Medicine

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