Figure1: Design and mechanism of ADA@MOF-EPL (IMAGE)

Science China Press

Figure1: Design and mechanism of ADA@MOF-EPL

Caption

Schematic illustration of ADA@MOF-EPL synthesis and its therapeutic mechanism. ADA@MOF-EPL enters the cell and accumulates near the nucleus membrane via estrone-mediated endocytosis. The acidic TME leads to the destabilization of nanoparticle structure, resulting in the initial release of ADA to inhibit WEE1 for DNA damage response. Finally, US irradiation stimulates ADA@MOF-EPL to further release ADA and generate ROS for DNA damage via SDT, leading to cell apoptosis.

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