Figure01 (IMAGE)

The University of Hong Kong

Figure01

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Figure 1. Interorgan communication between neurons and intestine in C. elegans PD model. Mitochondrial stress in neurons caused by a-syn aggregation induces the secretion of signalling molecules (mitokines) that activate mitochondrial unfolded protein response (mitoUPR) and inhibit propionate production in the intestine. Reduced abundance of propionate downregulates metabolic genes, leading to deficits in energy production. Intestinal energy failure exacerbates neurodegeneration by reducing the release of lactate and insulin-like peptides. Image adapted from respective journal paper.

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The University of Hong Kong

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