Graphical abstract of the study (IMAGE) Kyushu University Caption Steroids-producing nodules, or SPNs, exhibit a two-layered zona fasciculata (zF) and zona reticularis (zR) like structure, where two distinct cell populations might contribute differently to adrenocortical tumorigenesis. Credit Kyushu University/Ogawa Lab Usage Restrictions Only for media and non-commercial use. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.