Tracking a Protein’s Fleeting Shape Changes (IMAGE)

Weill Cornell Medicine

Tracking a Protein’s Fleeting Shape Changes

Caption

High-Speed Atomic Force Microscopy allowed the characterization of the entire landscape of structural shapes that the amino acid transporter could adopt (yellow-red area with population density lines) between its open (A,B,C) and closed (D,E) states. The molecules in one corner of the conformational landscape (top right, red) were found to be trapped in an inactive state.

Credit

Scheuring lab

Usage Restrictions

N/A

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.