Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota (IMAGE)
Caption
Astragalus Polysaccharide alleviates the reduction of VRC metabolism induced by LPS by inhibiting lipid accumulation and inflammatory cytokine levels in the serum and liver and improving the metabolic function of the liver. VRC metabolism was increased by increasing the abundance of B. bifidum in the intestine, reducing the secretion of anti-inflammatory factors in the liver, and increasing the activity of CYP2C19 . In particular, high-dose APS (600 mg/kg) more strongly improved VRC metabolism. These results provide important insights into the pharmacological mechanism of action of APS and the development of clinical preparations.
Credit
Maoxun Yang, Jinbin Wei, Xiaokang Wang, Xianjing Hu
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CC BY-NC