PET imaging of 124I-αGal-1 predicts ICB therapy. (IMAGE)
Caption
Figure 4. PET imaging of 124I-αGal-1 predicts ICB therapy. (A) PET/CT images and quantified tumor uptake of 124I-αGal-1 72 h after injection in 4T1 tumor–bearing mice, classified into high- and low-tumor-uptake groups (cutoff, 3.4 percentage injected dose per gram [%ID/g]) (n = 4/group). White arrows indicate tumors. (B) Tumor growth curves for 4T1 tumor–bearing mice in high- and low-tumor-uptake groups of 124I-αGal-1 after ICB therapy (n = 5/group). (C) Western blot analysis and quantitative assessment of Gal-1 levels in high- and low-tumor-uptake groups of 124I-αGal-1 (n = 4/group). All numeric data are presented as mean ± SD. *P < 0.05; **P < 0.01. α = anti-; i.p. = intraperitoneally.
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Image created by N Liu and X Yang, et al. Peking University, Beijing, China.
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