A working model of the cytopathic effect of HBc (IMAGE)
Caption
HBc inhibits damage-induced mitochondrial fission and selective mitophagy. HBc-triggered Rab7 hyperactivation increases lysosomal fusion while preventing autophagic lysosome reformation. Sustained HBc expression may thus lead to lysosomal consumption which further inhibits late-stage autophagy and exacerbates oxidative stress.
Credit
©Science China Press
Usage Restrictions
Use with credit.
License
Original content