Chemoproteomics enables identification of coatomer subunit zeta-1 targeted by a small molecule for enterovirus A71 inhibition (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Chemoproteomics enables identification of coatomer subunit zeta-1 targeted by a small molecule for enterovirus A71 inhibition

Caption

MPA-CF3 specifically binds to COPZ1, a subunit of COPI. Upon binding, MPA-CF3 destabilizes COPZ1 and disrupts the interaction of COPZ1 with the EV-A71 2C protein in a concentration-dependent manner. The destruction of this interaction blocks the COPI coat-mediated transport of 2C to ER and ultimately inhibits EV-A71 replication.

Credit

Researcher Wu Zhong, Prof. Yong Qin

Usage Restrictions

not applicable

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.