Figure 1. Regulatory T cells continue to exhibit inflammatory features even after clearance of the hepatitis C Virus (IMAGE)

Institute for Basic Science

Figure 1. Regulatory T cells continue to exhibit inflammatory features even after clearance of the hepatitis C Virus

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The number of regulatory T cells remains elevated in the peripheral blood of chronic hepatitis C patients, and this increase remains persistent even after the completion of treatment. Analysis of the transcriptome and epigenome of patients with chronic hepatitis C show that regulatory T cells continue to have increased inflammatory characteristics compared to normal people. These inflammatory TREG cells showed higher expression levels of activation markers and transcription factors such as RORγt and T-bet, leading them to secrete inflammatory cytokine TNF.

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Institute for Basic Science

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