GlycoRNA (IMAGE)

Harvard University

GlycoRNA

Caption

Cellular transfer RNAs (tRNAs) are synthesized in the nucleus and can be modified there or in the cytosol to create “acp3U” residue. A subsequent conversion to the carboxamide functionality, by an as-yet unknown enzyme, then allows translocation into the endoplasmic reticulum (ER) lumen. Once in the ER lumen, carboxamide form of acp3U would then enable N-glycosylation. Further trafficking through the secretory pathway accompanied by N-glycan trimming and branch extensions would then produce mature sialoglycoRNAs on the cell surface.

Credit

Flynn Lab

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None

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