(IMAGE)

Tokyo Medical and Dental University

Caption

Through a comprehensive genetic analysis of patients with PKD but no family history of the disease, researchers found that a mutation in the IFT140 gene was significantly prevalent. Compared to patients with mutations in more commonly affected genes, PKD in people with an IFT140 mutation usually manifested in a milder form—their total kidney volume (TKV) was lower, and the cysts were sometimes asymmetric.

Credit

Department of Nephrology, TMDU

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