The combination of AZD1775 and actinomycin D efficiently promotes ferroptosis in cancer cells (IMAGE)

Science China Press

The combination of AZD1775 and actinomycin D efficiently promotes ferroptosis in cancer cells

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AZD1775 plays a role in the regulation of ferroptosis by dually targeting the cystine uptake and the WEE1-SETDB1 axis, while the activation of the p53-SLC7A11 cascade by Act. D augments AZD1775-induced ferroptosis to suppress cancers harboring wild-type p53.

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