Evolutionary Trajectory of TRPM2 activation (IMAGE)
Caption
The mode of TRPM2 channel activation by ADPR and Ca2+ evolved through at least three identifiable stages, from a relatively simple one in TRPM2s from Cnidaria, such as the nvTRPM2, to an intermediate one in TRPM2 channels from fish, represented by the olTRPM2, and to a more complicated and coordinated one as in the hsTRPM2.
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